Head-to-head
Direct Meds vs Enhance MD
Compared on both medications across the eight dimensions this database records. They differ on 3 of those eight. Enhance MD is cheaper on all-in tirzepatide at 10 mg/week, though on a flat-versus-tiered matchup the cheaper program can change further up the dose ladder.
The short answer
Direct Meds is $399 a month all-in for tirzepatide; Enhance MD is $280. Over twelve months that is $4,788 against $3,360. Value Scores are 45.1 and 57.8 out of 100.
Tirzepatide
Plan pages: Direct Meds plans · Enhance MD plans
At 10 mg/week, Direct Meds is $399 a month all-in and Enhance MD is $280 — $119 apart, or $1,428 across a year. Over twelve months the totals are $4,788 (billed monthly) and $3,360 (billed monthly).
Direct Meds prices tirzepatide by dose: $299 per month at 2.5 mg rising to $399 at 10 mg, a difference of $100 a month between the bottom and top of the ladder. The company publishes no price at 5, 7.5, 12.5, 15 mg, so those doses are left blank rather than estimated.
Enhance MD prices tirzepatide by dose: $169 per month at 2.5 mg rising to $280 at 10 mg, a difference of $111 a month between the bottom and top of the ladder. The company publishes no price at 5, 7.5, 12.5, 15 mg, so those doses are left blank rather than estimated.
| Dose | Direct Meds | Rank | Enhance MD | Rank | Cheaper |
|---|---|---|---|---|---|
| 2.5 mg | $299 | 17/31 | $169 | 2/31 | Enhance MD by $130 |
| 5 mg | — | — | — | — | neither publishes |
| 7.5 mg | — | — | — | — | neither publishes |
| 10 mg | $399 | 20/27 | $280 | 9/27 | Enhance MD by $119 |
| 12.5 mg | — | — | — | — | neither publishes |
| 15 mg | — | — | — | — | neither publishes |
Enhance MD is cheaper at every dose where both publish a price, so the lead does not change as you titrate.
Across the 27 programs this database can rank on tirzepatide, Direct Meds sits 22 of 27 on all-in monthly cost and Enhance MD sits 7. There are 14 other programs priced between them. The field median is $339 and the floor is $169, so Enhance MD is below the median and the other is above it. Direct Meds is $230 above the cheapest tirzepatide program on record. Enhance MD is $111 above the cheapest tirzepatide program on record.
LillyDirect (Zepbound), the lowest FDA-approved tirzepatide channel here, is $449 a month — Direct Meds undercuts it by $50, Enhance MD by $169. Compounded products are not FDA approved; insurance can reverse that comparison.
| Plan term | Direct Meds | Enhance MD | Cheaper |
|---|---|---|---|
| Month to month | $399 | $280 | Enhance MD by $119 |
| Settled dose | Direct Meds | Enhance MD | Difference |
|---|---|---|---|
| 2.5 mg | $3,588 | $2,028 | $1,560 apart |
| 10 mg | $4,788 | $3,360 | $1,428 apart |
Direct Meds publishes no rate for 3-month term, 6-month term, 12-month term; Enhance MD publishes none for 3-month term, 6-month term, 12-month term. An unpublished term is not necessarily unavailable — it is unpriced in public, which you can only resolve by asking.
A titration year is not twelve months at the maintenance price. Stepping up roughly four weeks per dose before settling at 10 mg/week, the first twelve months work out to $4,688 on Direct Meds and $3,249 on Enhance MD — $1,439 apart, and a different gap from the $1,428 you would get by multiplying the monthly difference by twelve. The ramp is cheaper than the settled rate on whichever program prices by dose, which is why a first-year quote and a steady-state quote are not the same number.
That calculation is partial: Direct Meds publishes no price at 2 of the 6 doses and Enhance MD publishes no price at 2 of them, so the maintenance rate stands in for the missing steps rather than a number the company has stated.
Value Scores are 45.1 for Direct Meds and 57.8 for Enhance MD, against a tirzepatide category floor of $169. Enhance MD leads by 12.7 points, driven mostly by price.
| Program | Price /70 | Evidence /15 | Dose /10 | Membership /5 | Total /100 |
|---|---|---|---|---|---|
| Direct Meds | 29.6 | 10.5 | 0 | 5 | 45.1 |
| Enhance MD | 42.2 | 10.5 | 0 | 5 | 57.8 |
Semaglutide
Plan pages: Direct Meds plans · Enhance MD plans
At 2.4 mg/week, Direct Meds is $297 a month all-in and Enhance MD is $212 — $85 apart, or $1,020 across a year. Over twelve months the totals are $3,564 (billed monthly) and $2,544 (billed monthly).
Direct Meds prices semaglutide by dose: $249 per month at 0.25 mg rising to $297 at 2.4 mg, a difference of $48 a month between the bottom and top of the ladder. The company publishes no price at 0.5, 1, 1.7 mg, so those doses are left blank rather than estimated.
Enhance MD charges a flat $212 per month for semaglutide at every dose from 0.25 to 2.4 mg per week, so titrating upward does not change what you pay.
Enhance MD is cheaper at every dose where both publish a price, so the lead does not change as you titrate.
Value Scores are 45.9 for Direct Meds and 58.1 for Enhance MD, against a semaglutide category floor of $129. Enhance MD leads by 12.2 points, driven mostly by price.
Where the two programs differ
All-in monthly
Enhance MD is cheaper month to month — $280 against $399, a gap of $119 every month, or $1,428 across a year if both rates hold.
Commitment
Direct Meds asks for Monthly (no commitment indicated); Enhance MD asks for Monthly, with a first-month discount on GLP-1 Core ($112 first month). This is the dimension most likely to change which program is actually cheaper for you, because the lowest rates on both sides are usually attached to the longest terms.
Twelve-month cost
Over twelve months the totals are $4,788 for Direct Meds and $3,360 for Enhance MD. Enhance MD is lower by $1,428 — a figure worth checking against the cancellation terms below, because a prepaid year is only cheaper if you stay on it.
Cancellation terms
Both state the same cancellation terms: Per provider terms.
Dose policy
Both price by dose, so both advertised figures understate the cost of a titration year. Compare the ladders above rather than the headline rates.
Evidence status
Both figures carry the same evidence status, reported: sourced from dated third-party reporting; first-party capture pending. Neither is stronger than the other on provenance.
Membership fee
Neither charges a separate membership fee.
Shipping
Shipping is handled the same way by both — included in the quoted price.
What each record says
Direct Meds Official site
Direct Meds offers compounded GLP-1s in multiple formats — sublingual and injectable — with all-inclusive pricing verified on its own product pages. Semaglutide runs $249–$297/mo and tirzepatide $299–$399/mo depending on format; the lower figures are for sublingual delivery.
It does not publicly name its compounding pharmacy; the record shows Partner 503A pharmacy (not publicly named), so who actually makes the medication cannot be independently verified; commitment terms are Monthly (no commitment indicated); cancellation is Per provider terms; availability is stated as Confirm at intake.
Evidence: reported — sourced from dated third-party reporting; first-party capture pending, captured . Source — rangeyourself.com, Direct Meds product pages verified 2026-07-25
Watch: Pricing varies by format and page; product-page 'all-inclusive' rates differ from homepage promo cards. Rank is based on injectable rate as primary. Reported status — RangeYourself verified 2026-07-25 on Direct Meds' own product pages.
Enhance MD Official site
Enhance MD bundles GLP-1 medication inside a broader metabolic program including NAD+ coaching, lab testing every six months, and ongoing provider care. The price reflects the full metabolic bundle, not the GLP-1 alone; this makes Enhance MD's figures the least comparable in the database.
It does not publicly name its compounding pharmacy; the record shows Partner 503A pharmacy (not named), so who actually makes the medication cannot be independently verified; commitment terms are Monthly, with a first-month discount on GLP-1 Core ($112 first month); cancellation is Per provider terms; availability is stated as Confirm at intake.
Evidence: reported — sourced from dated third-party reporting; first-party capture pending, captured . Source — rangeyourself.com, Enhance MD verified 2026-07-14; price reflects metabolic bundle, not GLP-1 alone
Watch: Figures reflect the bundled metabolic program price, not GLP-1 medication alone. Comparing Enhance MD's $212–$322 to medication-only programs overstates the GLP-1 cost while understating the breadth of service included. The $169 microdosing figure is the most medication-proximate but involves a different dosing protocol. Reported — RangeYourself 2026-07-14.
What neither record tells you
Direct Meds does not publish
- no tirzepatide price at 5, 7.5, 12.5, 15 mg per week
- no published twelve-month tirzepatide rate
- no semaglutide price at 0.5, 1, 1.7 mg per week
- no published twelve-month semaglutide rate
- no named compounding pharmacy
- no state-by-state availability list — it says Confirm at intake
- no specific cancellation or refund terms
Enhance MD does not publish
- no tirzepatide price at 5, 7.5, 12.5, 15 mg per week
- no published twelve-month tirzepatide rate
- no published twelve-month semaglutide rate
- no named compounding pharmacy
- no state-by-state availability list — it says Confirm at intake
- no specific cancellation or refund terms
Ask Direct Meds and Enhance MD for each of those in writing before enrolling. A gap is not evidence of a problem; it does mean nothing can be checked against it.
What would change this answer
Evidence may be upgraded. Direct Meds, Enhance MD carry a price we have not captured at checkout. A capture would move the evidence term and could reorder these two without any price changing.
Which one suits which reader
On the lowest standing monthly rate for tirzepatide, Enhance MD Official site wins this matchup. On the structural dimensions the two are close enough that the choice comes down to availability in your state and which intake you prefer.
Both figures should be checked at the provider's own checkout before you pay. Direct Meds's tirzepatide price is reported as of 2026-07-25; Enhance MD's is reported as of 2026-07-14.
Questions
Is Direct Meds or Enhance MD cheaper for tirzepatide?
Enhance MD is cheaper on all-in monthly cost at 10 mg/week: $280 against $399, a difference of $119 a month. All-in means the medication plus every mandatory recurring fee.
What is the twelve-month cost of Direct Meds versus Enhance MD?
Direct Meds works out to $4,788 across twelve months and Enhance MD to $3,360, on the plan terms each publishes.
Does Direct Meds or Enhance MD raise the price as the dose goes up?
Direct Meds: yes, it prices by dose. Enhance MD: yes, it prices by dose. Where one program is flat and the other is tiered, the cheaper of the two can change as you titrate upward.
How many ways do Direct Meds and Enhance MD differ?
3 of the eight dimensions this site records: all-in monthly, twelve-month cost, dose policy, membership, shipping, commitment, cancellation terms and evidence status.
Which of Direct Meds and Enhance MD names its pharmacy?
Neither. Direct Meds records Partner 503A pharmacy (not publicly named) and Enhance MD records Partner 503A pharmacy (not named). Without a named pharmacy, neither program's licensing or inspection history can be checked before you order.
How well evidenced are the Direct Meds and Enhance MD prices?
Direct Meds's tirzepatide figure is reported — sourced from dated third-party reporting; first-party capture pending — captured 2026-07-25. Enhance MD's is reported, captured 2026-07-14. Evidence status is worth fifteen points in the Value Score, so it is priced in rather than mentioned as an aside.
Which is cheaper for semaglutide?
Enhance MD, at $212 a month all-in against $297 at 2.4 mg/week. The two programs do not necessarily lead on both medications.
Official sources: Direct Meds official site · Enhance MD official site. Compounded tirzepatide and semaglutide are not FDA-approved products.