Head-to-head
LifeMD vs Enhance MD
Compared on both medications across the eight dimensions this database records. They differ on 7 of those eight. Enhance MD is cheaper on all-in tirzepatide at 10 mg/week, though on a flat-versus-tiered matchup the cheaper program can change further up the dose ladder.
The short answer
LifeMD is $746 a month all-in for tirzepatide; Enhance MD is $280. Over twelve months that is $8,952 against $3,360. Value Scores are 38.6 and 57.8 out of 100.
Tirzepatide
Plan pages: LifeMD plans · Enhance MD plans
At 10 mg/week, LifeMD is $746 a month all-in and Enhance MD is $280 — $466 apart, or $5,592 across a year. Over twelve months the totals are $8,952 (billed monthly) and $3,360 (billed monthly).
LifeMD charges a flat $597 per month for tirzepatide at every dose from 2.5 to 15 mg per week, so titrating upward does not change what you pay.
Enhance MD prices tirzepatide by dose: $169 per month at 2.5 mg rising to $280 at 10 mg, a difference of $111 a month between the bottom and top of the ladder. The company publishes no price at 5, 7.5, 12.5, 15 mg, so those doses are left blank rather than estimated.
| Dose | LifeMD | Rank | Enhance MD | Rank | Cheaper |
|---|---|---|---|---|---|
| 2.5 mg | $597 | 31/31 | $169 | 2/31 | Enhance MD by $428 |
| 5 mg | $597 | 17/17 | — | — | only LifeMD publishes |
| 7.5 mg | $597 | 17/17 | — | — | only LifeMD publishes |
| 10 mg | $597 | 26/27 | $280 | 9/27 | Enhance MD by $317 |
| 12.5 mg | $597 | 17/17 | — | — | only LifeMD publishes |
| 15 mg | $597 | 17/17 | — | — | only LifeMD publishes |
Enhance MD is cheaper at every dose where both publish a price, so the lead does not change as you titrate.
Across the 27 programs this database can rank on tirzepatide, LifeMD sits 26 of 27 on all-in monthly cost and Enhance MD sits 7. There are 18 other programs priced between them. The field median is $339 and the floor is $169, so Enhance MD is below the median and the other is above it. LifeMD is $577 above the cheapest tirzepatide program on record. Enhance MD is $111 above the cheapest tirzepatide program on record.
LillyDirect (Zepbound), the lowest FDA-approved tirzepatide channel here, is $449 a month — LifeMD undercuts it by $-297, Enhance MD by $169. Compounded products are not FDA approved; insurance can reverse that comparison.
| Plan term | LifeMD | Enhance MD | Cheaper |
|---|---|---|---|
| Month to month | $597 | $280 | Enhance MD by $317 |
| Settled dose | LifeMD | Enhance MD | Difference |
|---|---|---|---|
| 2.5 mg | $8,952 | $2,028 | $6,924 apart |
| 5 mg | $8,952 | — | one side unpriced |
| 7.5 mg | $8,952 | — | one side unpriced |
| 10 mg | $8,952 | $3,360 | $5,592 apart |
| 12.5 mg | $8,952 | — | one side unpriced |
| 15 mg | $8,952 | — | one side unpriced |
LifeMD publishes no rate for 3-month term, 6-month term, 12-month term; Enhance MD publishes none for 3-month term, 6-month term, 12-month term. An unpublished term is not necessarily unavailable — it is unpriced in public, which you can only resolve by asking.
A titration year is not twelve months at the maintenance price. Stepping up roughly four weeks per dose before settling at 10 mg/week, the first twelve months work out to $8,952 on LifeMD and $3,249 on Enhance MD — $5,703 apart, and a different gap from the $5,592 you would get by multiplying the monthly difference by twelve. The ramp is cheaper than the settled rate on whichever program prices by dose, which is why a first-year quote and a steady-state quote are not the same number.
That calculation is partial: Enhance MD publishes no price at 2 of them, so the maintenance rate stands in for the missing steps rather than a number the company has stated.
Value Scores are 38.6 for LifeMD and 57.8 for Enhance MD, against a tirzepatide category floor of $169. Enhance MD leads by 19.2 points, driven mostly by price.
| Program | Price /70 | Evidence /15 | Dose /10 | Membership /5 | Total /100 |
|---|---|---|---|---|---|
| LifeMD | 15.9 | 12.8 | 10 | 0 | 38.6 |
| Enhance MD | 42.2 | 10.5 | 0 | 5 | 57.8 |
Semaglutide
Plan pages: LifeMD plans · Enhance MD plans
At 2.4 mg/week, LifeMD is $497 a month all-in and Enhance MD is $212 — $285 apart, or $3,420 across a year. Over twelve months the totals are $5,964 (billed monthly) and $2,544 (billed monthly).
LifeMD charges a flat $348 per month for semaglutide at every dose from 0.25 to 2.4 mg per week, so titrating upward does not change what you pay.
Enhance MD charges a flat $212 per month for semaglutide at every dose from 0.25 to 2.4 mg per week, so titrating upward does not change what you pay.
Enhance MD is cheaper at every dose where both publish a price, so the lead does not change as you titrate.
Value Scores are 40.9 for LifeMD and 58.1 for Enhance MD, against a semaglutide category floor of $129. Enhance MD leads by 17.2 points, driven mostly by price.
Where the two programs differ
All-in monthly
Enhance MD is cheaper month to month — $280 against $746, a gap of $466 every month, or $5,592 across a year if both rates hold.
Cancellation terms
Cancellation differs: LifeMD states Cancel anytime, while Enhance MD states Per provider terms. Read this next to the twelve-month figures — a prepaid discount and a restrictive refund policy are the same decision.
Commitment
LifeMD asks for Month-to-month; Enhance MD asks for Monthly, with a first-month discount on GLP-1 Core ($112 first month). This is the dimension most likely to change which program is actually cheaper for you, because the lowest rates on both sides are usually attached to the longest terms.
Dose policy
LifeMD charges one price at every dose; Enhance MD prices by dose. That difference usually matters more than the headline gap, because the tiered program's advertised figure describes the dose you start on, not the dose you settle at.
Evidence status
The two prices are not equally well evidenced. LifeMD's figure is provider-stated and Enhance MD's is reported. LifeMD rests on the stronger of the two, and the Value Score below reflects that — evidence quality is worth fifteen points and is not a tiebreaker we apply after the fact.
Membership fee
LifeMD charges a membership of $149 a month on top of the medication. That is already folded into the all-in figures above — it is broken out here because a membership is a recurring charge that continues even in a month you skip a shipment.
Twelve-month cost
Over twelve months the totals are $8,952 for LifeMD and $3,360 for Enhance MD. Enhance MD is lower by $5,592 — a figure worth checking against the cancellation terms below, because a prepaid year is only cheaper if you stay on it.
Shipping
Shipping is handled the same way by both — included in the quoted price.
What each record says
LifeMD Official site
LifeMD attaches a $149/month program fee to medication pricing; its compounded tirzepatide all-in figure ($597) is the highest in our index, though its insurance-navigation pathway for brand products is a genuine strength.
It does not publicly name its compounding pharmacy; the record shows Partner pharmacies, so who actually makes the medication cannot be independently verified; commitment terms are Month-to-month; cancellation is Cancel anytime; availability is stated as 50 states.
Evidence: provider-stated — taken from the provider's own published pages; checkout capture pending, captured . Source — lifemd.com pricing capture 2026-08-05
Watch: Highest all-in compounded tirzepatide in the index; the value case rests on clinical service and insurance help, not price.
Enhance MD Official site
Enhance MD bundles GLP-1 medication inside a broader metabolic program including NAD+ coaching, lab testing every six months, and ongoing provider care. The price reflects the full metabolic bundle, not the GLP-1 alone; this makes Enhance MD's figures the least comparable in the database.
It does not publicly name its compounding pharmacy; the record shows Partner 503A pharmacy (not named), so who actually makes the medication cannot be independently verified; commitment terms are Monthly, with a first-month discount on GLP-1 Core ($112 first month); cancellation is Per provider terms; availability is stated as Confirm at intake.
Evidence: reported — sourced from dated third-party reporting; first-party capture pending, captured . Source — rangeyourself.com, Enhance MD verified 2026-07-14; price reflects metabolic bundle, not GLP-1 alone
Watch: Figures reflect the bundled metabolic program price, not GLP-1 medication alone. Comparing Enhance MD's $212–$322 to medication-only programs overstates the GLP-1 cost while understating the breadth of service included. The $169 microdosing figure is the most medication-proximate but involves a different dosing protocol. Reported — RangeYourself 2026-07-14.
What neither record tells you
LifeMD does not publish
- no published twelve-month tirzepatide rate
- no published twelve-month semaglutide rate
- no named compounding pharmacy
Enhance MD does not publish
- no tirzepatide price at 5, 7.5, 12.5, 15 mg per week
- no published twelve-month tirzepatide rate
- no published twelve-month semaglutide rate
- no named compounding pharmacy
- no state-by-state availability list — it says Confirm at intake
- no specific cancellation or refund terms
Ask LifeMD and Enhance MD for each of those in writing before enrolling. A gap is not evidence of a problem; it does mean nothing can be checked against it.
What would change this answer
Evidence may be upgraded. Enhance MD carries a price we have not captured at checkout. A capture would move the evidence term and could reorder these two without any price changing.
Which one suits which reader
On the lowest standing monthly rate for tirzepatide, Enhance MD Official site wins this matchup. If you expect to titrate to the top of the ladder, lifemd's flat pricing is worth more than the headline gap suggests; if you want to be able to pause without still paying, enhance md carries no membership; and if you would rather trust a better-evidenced number, lifemd's price rests on stronger provenance.
Both figures should be checked at the provider's own checkout before you pay. LifeMD's tirzepatide price is provider-stated as of 2026-08-05; Enhance MD's is reported as of 2026-07-14.
Questions
Is LifeMD or Enhance MD cheaper for tirzepatide?
Enhance MD is cheaper on all-in monthly cost at 10 mg/week: $280 against $746, a difference of $466 a month. All-in means the medication plus every mandatory recurring fee.
What is the twelve-month cost of LifeMD versus Enhance MD?
LifeMD works out to $8,952 across twelve months and Enhance MD to $3,360, on the plan terms each publishes.
Does LifeMD or Enhance MD raise the price as the dose goes up?
LifeMD: no, it charges one flat rate at every dose. Enhance MD: yes, it prices by dose. Where one program is flat and the other is tiered, the cheaper of the two can change as you titrate upward.
How many ways do LifeMD and Enhance MD differ?
7 of the eight dimensions this site records: all-in monthly, twelve-month cost, dose policy, membership, shipping, commitment, cancellation terms and evidence status.
Which of LifeMD and Enhance MD names its pharmacy?
Neither. LifeMD records Partner pharmacies and Enhance MD records Partner 503A pharmacy (not named). Without a named pharmacy, neither program's licensing or inspection history can be checked before you order.
How well evidenced are the LifeMD and Enhance MD prices?
LifeMD's tirzepatide figure is provider-stated — taken from the provider's own published pages; checkout capture pending — captured 2026-08-05. Enhance MD's is reported, captured 2026-07-14. Evidence status is worth fifteen points in the Value Score, so it is priced in rather than mentioned as an aside.
Which is cheaper for semaglutide?
Enhance MD, at $212 a month all-in against $497 at 2.4 mg/week. The two programs do not necessarily lead on both medications.
Official sources: LifeMD official site · Enhance MD official site. Compounded tirzepatide and semaglutide are not FDA-approved products.