Head-to-head
LillyDirect (Zepbound) vs Enhance MD
Compared on tirzepatide across the eight dimensions this database records. They differ on 5 of those eight. Enhance MD is cheaper on all-in tirzepatide at 10 mg/week, though on a flat-versus-tiered matchup the cheaper program can change further up the dose ladder.
The short answer
LillyDirect (Zepbound) is $449 a month all-in for tirzepatide; Enhance MD is $280. Over twelve months that is $5,388 against $3,360. Value Scores are 46.3 and 57.8 out of 100.
Tirzepatide
Plan pages: LillyDirect (Zepbound) plans · Enhance MD plans
At 10 mg/week, LillyDirect (Zepbound) is $449 a month all-in and Enhance MD is $280 — $169 apart, or $2,028 across a year. Over twelve months the totals are $5,388 (billed monthly) and $3,360 (billed monthly).
LillyDirect (Zepbound) prices tirzepatide by dose: $299 per month at 2.5 mg rising to $449 at 7.5 mg, a difference of $150 a month between the bottom and top of the ladder.
Enhance MD prices tirzepatide by dose: $169 per month at 2.5 mg rising to $280 at 10 mg, a difference of $111 a month between the bottom and top of the ladder. The company publishes no price at 5, 7.5, 12.5, 15 mg, so those doses are left blank rather than estimated.
| Dose | LillyDirect (Zepbound) | Rank | Enhance MD | Rank | Cheaper |
|---|---|---|---|---|---|
| 2.5 mg | $299 | 18/31 | $169 | 2/31 | Enhance MD by $130 |
| 5 mg | $399 | 14/17 | — | — | only LillyDirect (Zepbound) publishes |
| 7.5 mg | $449 | 16/17 | — | — | only LillyDirect (Zepbound) publishes |
| 10 mg | $449 | 24/27 | $280 | 9/27 | Enhance MD by $169 |
| 12.5 mg | $449 | 16/17 | — | — | only LillyDirect (Zepbound) publishes |
| 15 mg | $449 | 16/17 | — | — | only LillyDirect (Zepbound) publishes |
Enhance MD is cheaper at every dose where both publish a price, so the lead does not change as you titrate.
Across the 27 programs this database can rank on tirzepatide, LillyDirect (Zepbound) sits 23 of 27 on all-in monthly cost and Enhance MD sits 7. There are 15 other programs priced between them. The field median is $339 and the floor is $169, so Enhance MD is below the median and the other is above it. LillyDirect (Zepbound) is $280 above the cheapest tirzepatide program on record. Enhance MD is $111 above the cheapest tirzepatide program on record.
LillyDirect (Zepbound), the lowest FDA-approved tirzepatide channel here, is $449 a month — LillyDirect (Zepbound) undercuts it by $0, Enhance MD by $169. Compounded products are not FDA approved; insurance can reverse that comparison.
| Plan term | LillyDirect (Zepbound) | Enhance MD | Cheaper |
|---|---|---|---|
| Month to month | $449 | $280 | Enhance MD by $169 |
| Settled dose | LillyDirect (Zepbound) | Enhance MD | Difference |
|---|---|---|---|
| 2.5 mg | $3,588 | $2,028 | $1,560 apart |
| 5 mg | $4,788 | — | one side unpriced |
| 7.5 mg | $5,388 | — | one side unpriced |
| 10 mg | $5,388 | $3,360 | $2,028 apart |
| 12.5 mg | $5,388 | — | one side unpriced |
| 15 mg | $5,388 | — | one side unpriced |
LillyDirect (Zepbound) publishes no rate for 3-month term, 6-month term, 12-month term; Enhance MD publishes none for 3-month term, 6-month term, 12-month term. An unpublished term is not necessarily unavailable — it is unpriced in public, which you can only resolve by asking.
A titration year is not twelve months at the maintenance price. Stepping up roughly four weeks per dose before settling at 10 mg/week, the first twelve months work out to $5,188 on LillyDirect (Zepbound) and $3,249 on Enhance MD — $1,939 apart, and a different gap from the $2,028 you would get by multiplying the monthly difference by twelve. The ramp is cheaper than the settled rate on whichever program prices by dose, which is why a first-year quote and a steady-state quote are not the same number.
That calculation is partial: Enhance MD publishes no price at 2 of them, so the maintenance rate stands in for the missing steps rather than a number the company has stated.
Value Scores are 46.3 for LillyDirect (Zepbound) and 57.8 for Enhance MD, against a tirzepatide category floor of $169. Enhance MD leads by 11.5 points, driven mostly by price.
| Program | Price /70 | Evidence /15 | Dose /10 | Membership /5 | Total /100 |
|---|---|---|---|---|---|
| LillyDirect (Zepbound) | 26.4 | 15.0 | 0 | 5 | 46.3 |
| Enhance MD | 42.2 | 10.5 | 0 | 5 | 57.8 |
Where the two programs differ
All-in monthly
Enhance MD is cheaper month to month — $280 against $449, a gap of $169 every month, or $2,028 across a year if both rates hold.
Cancellation terms
Cancellation differs: LillyDirect (Zepbound) states No subscription lock, while Enhance MD states Per provider terms. Read this next to the twelve-month figures — a prepaid discount and a restrictive refund policy are the same decision.
Commitment
LillyDirect (Zepbound) asks for None; Journey Program pricing requires refill within 45 days on 7.5 mg+; Enhance MD asks for Monthly, with a first-month discount on GLP-1 Core ($112 first month). This is the dimension most likely to change which program is actually cheaper for you, because the lowest rates on both sides are usually attached to the longest terms.
Evidence status
The two prices are not equally well evidenced. LillyDirect (Zepbound)'s figure is verified and Enhance MD's is reported. LillyDirect (Zepbound) rests on the stronger of the two, and the Value Score below reflects that — evidence quality is worth fifteen points and is not a tiebreaker we apply after the fact.
Twelve-month cost
Over twelve months the totals are $5,388 for LillyDirect (Zepbound) and $3,360 for Enhance MD. Enhance MD is lower by $2,028 — a figure worth checking against the cancellation terms below, because a prepaid year is only cheaper if you stay on it.
Dose policy
Both price by dose, so both advertised figures understate the cost of a titration year. Compare the ladders above rather than the headline rates.
Membership fee
Neither charges a separate membership fee.
Shipping
Shipping is handled the same way by both — included in the quoted price.
What each record says
LillyDirect (Zepbound) Official site
The manufacturer's own cash channel for FDA-approved Zepbound single-dose vials: $299/month at 2.5 mg, $399 at 5 mg, and $449 for every dose from 7.5 to 15 mg through the Self Pay Journey Program — provided each refill lands within 45 days of the last, otherwise that refill reverts to $599–$1,049 by dose. This is the cheapest FDA-approved tirzepatide in the country and the benchmark every compounded price should be judged against.
It names its compounding pharmacy — Eli Lilly self-pay pharmacy (GiftHealth), recorded as Manufacturer direct — which can be checked against state board licensing and FDA inspection records before you order; commitment terms are None; Journey Program pricing requires refill within 45 days on 7.5 mg+; cancellation is No subscription lock; availability is stated as 50 states.
Evidence: verified — captured at checkout by our desk on the stated date, captured . Source — Lilly investor announcement Dec 1, 2025 + LillyDirect program pages; corroborated by drugs.com pricing review updated Jun 12, 2026
Watch: The 45-day refill window is the whole game: one late refill at 10 mg costs $699 instead of $449.
Enhance MD Official site
Enhance MD bundles GLP-1 medication inside a broader metabolic program including NAD+ coaching, lab testing every six months, and ongoing provider care. The price reflects the full metabolic bundle, not the GLP-1 alone; this makes Enhance MD's figures the least comparable in the database.
It does not publicly name its compounding pharmacy; the record shows Partner 503A pharmacy (not named), so who actually makes the medication cannot be independently verified; commitment terms are Monthly, with a first-month discount on GLP-1 Core ($112 first month); cancellation is Per provider terms; availability is stated as Confirm at intake.
Evidence: reported — sourced from dated third-party reporting; first-party capture pending, captured . Source — rangeyourself.com, Enhance MD verified 2026-07-14; price reflects metabolic bundle, not GLP-1 alone
Watch: Figures reflect the bundled metabolic program price, not GLP-1 medication alone. Comparing Enhance MD's $212–$322 to medication-only programs overstates the GLP-1 cost while understating the breadth of service included. The $169 microdosing figure is the most medication-proximate but involves a different dosing protocol. Reported — RangeYourself 2026-07-14.
Which molecules each one carries
LillyDirect (Zepbound) carries tirzepatide at $449 a month; does not offer semaglutide.
Enhance MD carries tirzepatide at $280 a month and semaglutide at $212 a month.
Comparable only on tirzepatide: they do not both publish a rankable semaglutide price. Switching molecule mid-treatment would mean changing provider.
What neither record tells you
LillyDirect (Zepbound) does not publish
- no published twelve-month tirzepatide rate
Enhance MD does not publish
- no tirzepatide price at 5, 7.5, 12.5, 15 mg per week
- no published twelve-month tirzepatide rate
- no named compounding pharmacy
- no state-by-state availability list — it says Confirm at intake
- no specific cancellation or refund terms
Ask LillyDirect (Zepbound) and Enhance MD for each of those in writing before enrolling. A gap is not evidence of a problem; it does mean nothing can be checked against it.
What would change this answer
Evidence may be upgraded. Enhance MD carries a price we have not captured at checkout. A capture would move the evidence term and could reorder these two without any price changing.
Which one suits which reader
On the lowest standing monthly rate for tirzepatide, Enhance MD Official site wins this matchup. And if you would rather trust a better-evidenced number, lillydirect (zepbound)'s price rests on stronger provenance.
Both figures should be checked at the provider's own checkout before you pay. LillyDirect (Zepbound)'s tirzepatide price is verified as of 2026-08-11; Enhance MD's is reported as of 2026-07-14.
Questions
Is LillyDirect (Zepbound) or Enhance MD cheaper for tirzepatide?
Enhance MD is cheaper on all-in monthly cost at 10 mg/week: $280 against $449, a difference of $169 a month. All-in means the medication plus every mandatory recurring fee.
What is the twelve-month cost of LillyDirect (Zepbound) versus Enhance MD?
LillyDirect (Zepbound) works out to $5,388 across twelve months and Enhance MD to $3,360, on the plan terms each publishes.
Does LillyDirect (Zepbound) or Enhance MD raise the price as the dose goes up?
LillyDirect (Zepbound): yes, it prices by dose. Enhance MD: yes, it prices by dose. Where one program is flat and the other is tiered, the cheaper of the two can change as you titrate upward.
How many ways do LillyDirect (Zepbound) and Enhance MD differ?
5 of the eight dimensions this site records: all-in monthly, twelve-month cost, dose policy, membership, shipping, commitment, cancellation terms and evidence status.
Which of LillyDirect (Zepbound) and Enhance MD names its pharmacy?
LillyDirect (Zepbound) does — Eli Lilly self-pay pharmacy (GiftHealth). Enhance MD does not, recording only Partner 503A pharmacy (not named), so who makes its medication cannot be independently verified.
How well evidenced are the LillyDirect (Zepbound) and Enhance MD prices?
LillyDirect (Zepbound)'s tirzepatide figure is verified — captured at checkout by our desk on the stated date — captured 2026-08-11. Enhance MD's is reported, captured 2026-07-14. Evidence status is worth fifteen points in the Value Score, so it is priced in rather than mentioned as an aside.
Official sources: LillyDirect (Zepbound) official site · Enhance MD official site. Compounded tirzepatide and semaglutide are not FDA-approved products.