Head-to-head
LillyDirect (Zepbound) vs HealthRX
Compared on tirzepatide across the eight dimensions this database records. They differ on 6 of those eight. HealthRX is cheaper on all-in tirzepatide at 10 mg/week, though on a flat-versus-tiered matchup the cheaper program can change further up the dose ladder.
The short answer
LillyDirect (Zepbound) is $449 a month all-in for tirzepatide; HealthRX is $209. Over twelve months that is $5,388 against $2,148. Value Scores are 46.3 and 82.1 out of 100.
Tirzepatide
Plan pages: LillyDirect (Zepbound) plans · HealthRX plans
At 10 mg/week, LillyDirect (Zepbound) is $449 a month all-in and HealthRX is $209 — $240 apart, or $2,880 across a year. Over twelve months the totals are $5,388 (billed monthly) and $2,148 (prepaid term).
LillyDirect (Zepbound) prices tirzepatide by dose: $299 per month at 2.5 mg rising to $449 at 7.5 mg, a difference of $150 a month between the bottom and top of the ladder.
HealthRX charges a flat $209 per month for tirzepatide at every dose from 2.5 to 15 mg per week, so titrating upward does not change what you pay.
| Dose | LillyDirect (Zepbound) | Rank | HealthRX | Rank | Cheaper |
|---|---|---|---|---|---|
| 2.5 mg | $299 | 18/31 | $209 | 11/31 | HealthRX by $90 |
| 5 mg | $399 | 14/17 | $209 | 5/17 | HealthRX by $190 |
| 7.5 mg | $449 | 16/17 | $209 | 5/17 | HealthRX by $240 |
| 10 mg | $449 | 24/27 | $209 | 5/27 | HealthRX by $240 |
| 12.5 mg | $449 | 16/17 | $209 | 5/17 | HealthRX by $240 |
| 15 mg | $449 | 16/17 | $209 | 5/17 | HealthRX by $240 |
HealthRX is cheaper at every dose where both publish a price, so the lead does not change as you titrate.
Across the 27 programs this database can rank on tirzepatide, LillyDirect (Zepbound) sits 23 of 27 on all-in monthly cost and HealthRX sits 5. There are 17 other programs priced between them. The field median is $339 and the floor is $169, so HealthRX is below the median and the other is above it. LillyDirect (Zepbound) is $280 above the cheapest tirzepatide program on record. HealthRX is $40 above the cheapest tirzepatide program on record.
LillyDirect (Zepbound), the lowest FDA-approved tirzepatide channel here, is $449 a month — LillyDirect (Zepbound) undercuts it by $0, HealthRX by $240. Compounded products are not FDA approved; insurance can reverse that comparison.
| Plan term | LillyDirect (Zepbound) | HealthRX | Cheaper |
|---|---|---|---|
| Month to month | $449 | — | only LillyDirect (Zepbound) publishes this term |
| 3-month term | — | $209 | only HealthRX publishes this term |
| 12-month term | — | $179 | only HealthRX publishes this term |
| Settled dose | LillyDirect (Zepbound) | HealthRX | Difference |
|---|---|---|---|
| 2.5 mg | $3,588 | $2,508 | $1,080 apart |
| 5 mg | $4,788 | $2,508 | $2,280 apart |
| 7.5 mg | $5,388 | $2,508 | $2,880 apart |
| 10 mg | $5,388 | $2,508 | $2,880 apart |
| 12.5 mg | $5,388 | $2,508 | $2,880 apart |
| 15 mg | $5,388 | $2,508 | $2,880 apart |
LillyDirect (Zepbound) publishes no rate for 3-month term, 6-month term, 12-month term; HealthRX publishes none for month to month, 6-month term. An unpublished term is not necessarily unavailable — it is unpriced in public, which you can only resolve by asking.
A titration year is not twelve months at the maintenance price. Stepping up roughly four weeks per dose before settling at 10 mg/week, the first twelve months work out to $5,188 on LillyDirect (Zepbound) and $2,508 on HealthRX — $2,680 apart, and a different gap from the $2,880 you would get by multiplying the monthly difference by twelve. The ramp is cheaper than the settled rate on whichever program prices by dose, which is why a first-year quote and a steady-state quote are not the same number.
Value Scores are 46.3 for LillyDirect (Zepbound) and 82.1 for HealthRX, against a tirzepatide category floor of $169. HealthRX leads by 35.8 points, driven mostly by price.
| Program | Price /70 | Evidence /15 | Dose /10 | Membership /5 | Total /100 |
|---|---|---|---|---|---|
| LillyDirect (Zepbound) | 26.4 | 15.0 | 0 | 5 | 46.3 |
| HealthRX | 56.6 | 10.5 | 10 | 5 | 82.1 |
Where the two programs differ
All-in monthly
HealthRX is cheaper month to month — $209 against $449, a gap of $240 every month, or $2,880 across a year if both rates hold.
Cancellation terms
Cancellation differs: LillyDirect (Zepbound) states No subscription lock, while HealthRX states Per provider terms; confirm at enrollment. Read this next to the twelve-month figures — a prepaid discount and a restrictive refund policy are the same decision.
Commitment
LillyDirect (Zepbound) asks for None; Journey Program pricing requires refill within 45 days on 7.5 mg+; HealthRX asks for 12-month or 3-month plans only; no month-to-month rate published. This is the dimension most likely to change which program is actually cheaper for you, because the lowest rates on both sides are usually attached to the longest terms.
Dose policy
HealthRX charges one price at every dose; LillyDirect (Zepbound) prices by dose. That difference usually matters more than the headline gap, because the tiered program's advertised figure describes the dose you start on, not the dose you settle at.
Evidence status
The two prices are not equally well evidenced. LillyDirect (Zepbound)'s figure is verified and HealthRX's is reported. LillyDirect (Zepbound) rests on the stronger of the two, and the Value Score below reflects that — evidence quality is worth fifteen points and is not a tiebreaker we apply after the fact.
Twelve-month cost
Over twelve months the totals are $5,388 for LillyDirect (Zepbound) and $2,148 for HealthRX. HealthRX is lower by $3,240 — a figure worth checking against the cancellation terms below, because a prepaid year is only cheaper if you stay on it.
Membership fee
Neither charges a separate membership fee.
Shipping
Shipping is handled the same way by both — included in the quoted price.
What each record says
LillyDirect (Zepbound) Official site
The manufacturer's own cash channel for FDA-approved Zepbound single-dose vials: $299/month at 2.5 mg, $399 at 5 mg, and $449 for every dose from 7.5 to 15 mg through the Self Pay Journey Program — provided each refill lands within 45 days of the last, otherwise that refill reverts to $599–$1,049 by dose. This is the cheapest FDA-approved tirzepatide in the country and the benchmark every compounded price should be judged against.
It names its compounding pharmacy — Eli Lilly self-pay pharmacy (GiftHealth), recorded as Manufacturer direct — which can be checked against state board licensing and FDA inspection records before you order; commitment terms are None; Journey Program pricing requires refill within 45 days on 7.5 mg+; cancellation is No subscription lock; availability is stated as 50 states.
Evidence: verified — captured at checkout by our desk on the stated date, captured . Source — Lilly investor announcement Dec 1, 2025 + LillyDirect program pages; corroborated by drugs.com pricing review updated Jun 12, 2026
Watch: The 45-day refill window is the whole game: one late refill at 10 mg costs $699 instead of $449.
HealthRX Official site
HealthRX offers flat per-dose compounded GLP-1 pricing on 12-month and 3-month commitment plans. Its $99/mo semaglutide and $179/mo tirzepatide on the twelve-month plan rank among the lowest annualized figures in the market. No month-to-month rate is published.
It does not publicly name its compounding pharmacy; the record shows healthrx.com (pharmacy partner not publicly named), so who actually makes the medication cannot be independently verified; commitment terms are 12-month or 3-month plans only; no month-to-month rate published; cancellation is Per provider terms; confirm at enrollment; availability is stated as Confirm availability at intake.
Evidence: reported — sourced from dated third-party reporting; first-party capture pending, captured . Source — rangeyourself.com, capture verified 2026-07-18 on healthrx.com
Watch: HealthRX publishes no month-to-month rate; the $99/mo sema and $179/mo tirz are 12-month plan rates. The lowest commitment available is the 3-month plan ($133 sema, $209 tirz). Reported status — RangeYourself verified 2026-07-18 on healthrx.com; our independent checkout is pending.
Which molecules each one carries
LillyDirect (Zepbound) carries tirzepatide at $449 a month; does not offer semaglutide.
HealthRX carries tirzepatide at $209 a month and semaglutide at $133 a month.
Comparable only on tirzepatide: they do not both publish a rankable semaglutide price. Switching molecule mid-treatment would mean changing provider.
What neither record tells you
LillyDirect (Zepbound) does not publish
- no published twelve-month tirzepatide rate
HealthRX does not publish
- no named compounding pharmacy
- no state-by-state availability list — it says Confirm availability at intake
- no specific cancellation or refund terms
Ask LillyDirect (Zepbound) and HealthRX for each of those in writing before enrolling. A gap is not evidence of a problem; it does mean nothing can be checked against it.
What would change this answer
Evidence may be upgraded. HealthRX carries a price we have not captured at checkout. A capture would move the evidence term and could reorder these two without any price changing.
Prepaid terms move the annual figures. HealthRX publishes a twelve-month rate of $179 a month against $209 month-to-month. Read those next to the cancellation terms, not the monthly rate.
Which one suits which reader
On the lowest standing monthly rate for tirzepatide, HealthRX Official site wins this matchup. If you expect to titrate to the top of the ladder, healthrx's flat pricing is worth more than the headline gap suggests; and if you would rather trust a better-evidenced number, lillydirect (zepbound)'s price rests on stronger provenance.
Both figures should be checked at the provider's own checkout before you pay. LillyDirect (Zepbound)'s tirzepatide price is verified as of 2026-08-11; HealthRX's is reported as of 2026-07-18.
Questions
Is LillyDirect (Zepbound) or HealthRX cheaper for tirzepatide?
HealthRX is cheaper on all-in monthly cost at 10 mg/week: $209 against $449, a difference of $240 a month. All-in means the medication plus every mandatory recurring fee.
What is the twelve-month cost of LillyDirect (Zepbound) versus HealthRX?
LillyDirect (Zepbound) works out to $5,388 across twelve months and HealthRX to $2,148, on the plan terms each publishes.
Does LillyDirect (Zepbound) or HealthRX raise the price as the dose goes up?
LillyDirect (Zepbound): yes, it prices by dose. HealthRX: no, it charges one flat rate at every dose. Where one program is flat and the other is tiered, the cheaper of the two can change as you titrate upward.
How many ways do LillyDirect (Zepbound) and HealthRX differ?
6 of the eight dimensions this site records: all-in monthly, twelve-month cost, dose policy, membership, shipping, commitment, cancellation terms and evidence status.
Which of LillyDirect (Zepbound) and HealthRX names its pharmacy?
LillyDirect (Zepbound) does — Eli Lilly self-pay pharmacy (GiftHealth). HealthRX does not, recording only healthrx.com (pharmacy partner not publicly named), so who makes its medication cannot be independently verified.
How well evidenced are the LillyDirect (Zepbound) and HealthRX prices?
LillyDirect (Zepbound)'s tirzepatide figure is verified — captured at checkout by our desk on the stated date — captured 2026-08-11. HealthRX's is reported, captured 2026-07-18. Evidence status is worth fifteen points in the Value Score, so it is priced in rather than mentioned as an aside.
Official sources: LillyDirect (Zepbound) official site · HealthRX official site. Compounded tirzepatide and semaglutide are not FDA-approved products.