Head-to-head
Ro (Ro Body) vs LillyDirect (Zepbound)
Compared on tirzepatide across the eight dimensions this database records. They differ on 6 of those eight. LillyDirect (Zepbound) is cheaper on all-in tirzepatide at 10 mg/week, though on a flat-versus-tiered matchup the cheaper program can change further up the dose ladder.
The short answer
Ro (Ro Body) is $747 a month all-in for tirzepatide; LillyDirect (Zepbound) is $449. Over twelve months that is $8,964 against $5,388. Value Scores are 26.3 and 46.3 out of 100.
Tirzepatide
Plan pages: Ro (Ro Body) plans · LillyDirect (Zepbound) plans
At 10 mg/week, Ro (Ro Body) is $747 a month all-in and LillyDirect (Zepbound) is $449 — $298 apart, or $3,576 across a year. Over twelve months the totals are $8,964 (billed monthly) and $5,388 (billed monthly).
Ro (Ro Body) prices tirzepatide by dose: $448 per month at 2.5 mg rising to $598 at 10 mg, a difference of $150 a month between the bottom and top of the ladder. The company publishes no price at 5, 7.5, 12.5, 15 mg, so those doses are left blank rather than estimated.
LillyDirect (Zepbound) prices tirzepatide by dose: $299 per month at 2.5 mg rising to $449 at 7.5 mg, a difference of $150 a month between the bottom and top of the ladder.
| Dose | Ro (Ro Body) | Rank | LillyDirect (Zepbound) | Rank | Cheaper |
|---|---|---|---|---|---|
| 2.5 mg | $448 | 29/31 | $299 | 18/31 | LillyDirect (Zepbound) by $149 |
| 5 mg | — | — | $399 | 14/17 | only LillyDirect (Zepbound) publishes |
| 7.5 mg | — | — | $449 | 16/17 | only LillyDirect (Zepbound) publishes |
| 10 mg | $598 | 27/27 | $449 | 24/27 | LillyDirect (Zepbound) by $149 |
| 12.5 mg | — | — | $449 | 16/17 | only LillyDirect (Zepbound) publishes |
| 15 mg | — | — | $449 | 16/17 | only LillyDirect (Zepbound) publishes |
LillyDirect (Zepbound) is cheaper at every dose where both publish a price, so the lead does not change as you titrate.
Across the 27 programs this database can rank on tirzepatide, Ro (Ro Body) sits 27 of 27 on all-in monthly cost and LillyDirect (Zepbound) sits 23. There are 3 other programs priced between them. The field median is $339 and the floor is $169, so both sit above the median. Ro (Ro Body) is $578 above the cheapest tirzepatide program on record. LillyDirect (Zepbound) is $280 above the cheapest tirzepatide program on record.
LillyDirect (Zepbound), the lowest FDA-approved tirzepatide channel here, is $449 a month — Ro (Ro Body) undercuts it by $-298, LillyDirect (Zepbound) by $0. Compounded products are not FDA approved; insurance can reverse that comparison.
| Plan term | Ro (Ro Body) | LillyDirect (Zepbound) | Cheaper |
|---|---|---|---|
| Month to month | $598 | $449 | LillyDirect (Zepbound) by $149 |
| Settled dose | Ro (Ro Body) | LillyDirect (Zepbound) | Difference |
|---|---|---|---|
| 2.5 mg | $7,164 | $3,588 | $3,576 apart |
| 5 mg | — | $4,788 | one side unpriced |
| 7.5 mg | — | $5,388 | one side unpriced |
| 10 mg | $8,964 | $5,388 | $3,576 apart |
| 12.5 mg | — | $5,388 | one side unpriced |
| 15 mg | — | $5,388 | one side unpriced |
Ro (Ro Body) publishes no rate for 3-month term, 6-month term, 12-month term; LillyDirect (Zepbound) publishes none for 3-month term, 6-month term, 12-month term. An unpublished term is not necessarily unavailable — it is unpriced in public, which you can only resolve by asking.
A titration year is not twelve months at the maintenance price. Stepping up roughly four weeks per dose before settling at 10 mg/week, the first twelve months work out to $8,814 on Ro (Ro Body) and $5,188 on LillyDirect (Zepbound) — $3,626 apart, and a different gap from the $3,576 you would get by multiplying the monthly difference by twelve. The ramp is cheaper than the settled rate on whichever program prices by dose, which is why a first-year quote and a steady-state quote are not the same number.
That calculation is partial: Ro (Ro Body) publishes no price at 2 of the 6 doses, so the maintenance rate stands in for the missing steps rather than a number the company has stated.
Value Scores are 26.3 for Ro (Ro Body) and 46.3 for LillyDirect (Zepbound), against a tirzepatide category floor of $169. LillyDirect (Zepbound) leads by 20.0 points, driven mostly by price.
| Program | Price /70 | Evidence /15 | Dose /10 | Membership /5 | Total /100 |
|---|---|---|---|---|---|
| Ro (Ro Body) | 15.8 | 10.5 | 0 | 0 | 26.3 |
| LillyDirect (Zepbound) | 26.4 | 15.0 | 0 | 5 | 46.3 |
Where the two programs differ
All-in monthly
LillyDirect (Zepbound) is cheaper month to month — $449 against $747, a gap of $298 every month, or $3,576 across a year if both rates hold.
Cancellation terms
Cancellation differs: Ro (Ro Body) states Cancel anytime, while LillyDirect (Zepbound) states No subscription lock. Read this next to the twelve-month figures — a prepaid discount and a restrictive refund policy are the same decision.
Commitment
Ro (Ro Body) asks for Membership month-to-month ($39 first month; ~$74/mo prepaid annual); LillyDirect (Zepbound) asks for None; Journey Program pricing requires refill within 45 days on 7.5 mg+. This is the dimension most likely to change which program is actually cheaper for you, because the lowest rates on both sides are usually attached to the longest terms.
Evidence status
The two prices are not equally well evidenced. Ro (Ro Body)'s figure is reported and LillyDirect (Zepbound)'s is verified. LillyDirect (Zepbound) rests on the stronger of the two, and the Value Score below reflects that — evidence quality is worth fifteen points and is not a tiebreaker we apply after the fact.
Membership fee
Ro (Ro Body) charges a membership of $149 a month on top of the medication. That is already folded into the all-in figures above — it is broken out here because a membership is a recurring charge that continues even in a month you skip a shipment.
Twelve-month cost
Over twelve months the totals are $8,964 for Ro (Ro Body) and $5,388 for LillyDirect (Zepbound). LillyDirect (Zepbound) is lower by $3,576 — a figure worth checking against the cancellation terms below, because a prepaid year is only cheaper if you stay on it.
Dose policy
Both price by dose, so both advertised figures understate the cost of a titration year. Compare the ladders above rather than the headline rates.
Shipping
Shipping is handled the same way by both — included in the quoted price.
What each record says
Ro (Ro Body) Official site
Ro exited compounded GLP-1s in 2026 and now pairs a $39-then-$149/month membership (about $74/month prepaid annually) with brand-only medication: Wegovy pill from $149, Wegovy pen from $199 promotional / $349 standard, and Zepbound from $299 to $449 by dose. Its insurance concierge — benefits checks, prior authorizations, appeals — is the strongest in the category and can take a covered patient to a $25 copay.
It names its compounding pharmacy — Brand fulfillment via NovoCare / LillyDirect pathways, recorded as Brand channel + insurance concierge — which can be checked against state board licensing and FDA inspection records before you order; commitment terms are Membership month-to-month ($39 first month; ~$74/mo prepaid annual); cancellation is Cancel anytime; availability is stated as 50 states.
Evidence: reported — sourced from dated third-party reporting; first-party capture pending, captured . Source — Ro pricing pages as reported Jul 2026 ($149 membership + Zepbound $299–$449 by dose); first-party checkout capture pending
Watch: Cash-pay all-in runs ~$448–$598/month at maintenance; Ro's value case is insurance navigation, not cash price.
LillyDirect (Zepbound) Official site
The manufacturer's own cash channel for FDA-approved Zepbound single-dose vials: $299/month at 2.5 mg, $399 at 5 mg, and $449 for every dose from 7.5 to 15 mg through the Self Pay Journey Program — provided each refill lands within 45 days of the last, otherwise that refill reverts to $599–$1,049 by dose. This is the cheapest FDA-approved tirzepatide in the country and the benchmark every compounded price should be judged against.
It names its compounding pharmacy — Eli Lilly self-pay pharmacy (GiftHealth), recorded as Manufacturer direct — which can be checked against state board licensing and FDA inspection records before you order; commitment terms are None; Journey Program pricing requires refill within 45 days on 7.5 mg+; cancellation is No subscription lock; availability is stated as 50 states.
Evidence: verified — captured at checkout by our desk on the stated date, captured . Source — Lilly investor announcement Dec 1, 2025 + LillyDirect program pages; corroborated by drugs.com pricing review updated Jun 12, 2026
Watch: The 45-day refill window is the whole game: one late refill at 10 mg costs $699 instead of $449.
Which molecules each one carries
Ro (Ro Body) carries tirzepatide at $747 a month and semaglutide at $647 a month.
LillyDirect (Zepbound) carries tirzepatide at $449 a month; does not offer semaglutide.
Comparable only on tirzepatide: they do not both publish a rankable semaglutide price. Switching molecule mid-treatment would mean changing provider.
What neither record tells you
Ro (Ro Body) does not publish
- no tirzepatide price at 5, 7.5, 12.5, 15 mg per week
- no published twelve-month tirzepatide rate
LillyDirect (Zepbound) does not publish
- no published twelve-month tirzepatide rate
Ask Ro (Ro Body) and LillyDirect (Zepbound) for each of those in writing before enrolling. A gap is not evidence of a problem; it does mean nothing can be checked against it.
What would change this answer
Evidence may be upgraded. Ro (Ro Body) carries a price we have not captured at checkout. A capture would move the evidence term and could reorder these two without any price changing.
Which one suits which reader
On the lowest standing monthly rate for tirzepatide, LillyDirect (Zepbound) Official site wins this matchup. If you want to be able to pause without still paying, lillydirect (zepbound) carries no membership; and if you would rather trust a better-evidenced number, lillydirect (zepbound)'s price rests on stronger provenance.
Both figures should be checked at the provider's own checkout before you pay. Ro (Ro Body)'s tirzepatide price is reported as of 2026-08-11; LillyDirect (Zepbound)'s is verified as of 2026-08-11.
Questions
Is Ro (Ro Body) or LillyDirect (Zepbound) cheaper for tirzepatide?
LillyDirect (Zepbound) is cheaper on all-in monthly cost at 10 mg/week: $449 against $747, a difference of $298 a month. All-in means the medication plus every mandatory recurring fee.
What is the twelve-month cost of Ro (Ro Body) versus LillyDirect (Zepbound)?
Ro (Ro Body) works out to $8,964 across twelve months and LillyDirect (Zepbound) to $5,388, on the plan terms each publishes.
Does Ro (Ro Body) or LillyDirect (Zepbound) raise the price as the dose goes up?
Ro (Ro Body): yes, it prices by dose. LillyDirect (Zepbound): yes, it prices by dose. Where one program is flat and the other is tiered, the cheaper of the two can change as you titrate upward.
How many ways do Ro (Ro Body) and LillyDirect (Zepbound) differ?
6 of the eight dimensions this site records: all-in monthly, twelve-month cost, dose policy, membership, shipping, commitment, cancellation terms and evidence status.
Which of Ro (Ro Body) and LillyDirect (Zepbound) names its pharmacy?
Both do. Ro (Ro Body) names Brand fulfillment via NovoCare / LillyDirect pathways and LillyDirect (Zepbound) names Eli Lilly self-pay pharmacy (GiftHealth), so both can be checked against state board licensing and FDA inspection records.
How well evidenced are the Ro (Ro Body) and LillyDirect (Zepbound) prices?
Ro (Ro Body)'s tirzepatide figure is reported — sourced from dated third-party reporting; first-party capture pending — captured 2026-08-11. LillyDirect (Zepbound)'s is verified, captured 2026-08-11. Evidence status is worth fifteen points in the Value Score, so it is priced in rather than mentioned as an aside.
Official sources: Ro (Ro Body) official site · LillyDirect (Zepbound) official site. Compounded tirzepatide and semaglutide are not FDA-approved products.