Head-to-head
ShedRx vs Direct Meds
Compared on both medications across the eight dimensions this database records. They differ on 5 of those eight. ShedRx is cheaper on all-in tirzepatide at 10 mg/week, though on a flat-versus-tiered matchup the cheaper program can change further up the dose ladder.
The short answer
ShedRx is $289 a month all-in for tirzepatide; Direct Meds is $399. Over twelve months that is $3,468 against $4,788. Value Scores are 58.7 and 45.1 out of 100.
Tirzepatide
Plan pages: ShedRx plans · Direct Meds plans
At 10 mg/week, ShedRx is $289 a month all-in and Direct Meds is $399 — $110 apart, or $1,320 across a year. Over twelve months the totals are $3,468 (billed monthly) and $4,788 (billed monthly).
ShedRx prices tirzepatide by dose: $199 per month at 2.5 mg rising to $289 at 10 mg, a difference of $90 a month between the bottom and top of the ladder. The company publishes no price at 5, 7.5, 12.5, 15 mg, so those doses are left blank rather than estimated.
Direct Meds prices tirzepatide by dose: $299 per month at 2.5 mg rising to $399 at 10 mg, a difference of $100 a month between the bottom and top of the ladder. The company publishes no price at 5, 7.5, 12.5, 15 mg, so those doses are left blank rather than estimated.
| Dose | ShedRx | Rank | Direct Meds | Rank | Cheaper |
|---|---|---|---|---|---|
| 2.5 mg | $199 | 7/31 | $299 | 17/31 | ShedRx by $100 |
| 5 mg | — | — | — | — | neither publishes |
| 7.5 mg | — | — | — | — | neither publishes |
| 10 mg | $289 | 11/27 | $399 | 20/27 | ShedRx by $110 |
| 12.5 mg | — | — | — | — | neither publishes |
| 15 mg | — | — | — | — | neither publishes |
ShedRx is cheaper at every dose where both publish a price, so the lead does not change as you titrate.
Across the 27 programs this database can rank on tirzepatide, ShedRx sits 8 of 27 on all-in monthly cost and Direct Meds sits 22. There are 13 other programs priced between them. The field median is $339 and the floor is $169, so ShedRx is below the median and the other is above it. ShedRx is $120 above the cheapest tirzepatide program on record. Direct Meds is $230 above the cheapest tirzepatide program on record.
LillyDirect (Zepbound), the lowest FDA-approved tirzepatide channel here, is $449 a month — ShedRx undercuts it by $160, Direct Meds by $50. Compounded products are not FDA approved; insurance can reverse that comparison.
| Plan term | ShedRx | Direct Meds | Cheaper |
|---|---|---|---|
| Month to month | $289 | $399 | ShedRx by $110 |
| Settled dose | ShedRx | Direct Meds | Difference |
|---|---|---|---|
| 2.5 mg | $2,388 | $3,588 | $1,200 apart |
| 10 mg | $3,468 | $4,788 | $1,320 apart |
ShedRx publishes no rate for 3-month term, 6-month term, 12-month term; Direct Meds publishes none for 3-month term, 6-month term, 12-month term. An unpublished term is not necessarily unavailable — it is unpriced in public, which you can only resolve by asking.
A titration year is not twelve months at the maintenance price. Stepping up roughly four weeks per dose before settling at 10 mg/week, the first twelve months work out to $3,378 on ShedRx and $4,688 on Direct Meds — $1,310 apart, and a different gap from the $1,320 you would get by multiplying the monthly difference by twelve. The ramp is cheaper than the settled rate on whichever program prices by dose, which is why a first-year quote and a steady-state quote are not the same number.
That calculation is partial: ShedRx publishes no price at 2 of the 6 doses and Direct Meds publishes no price at 2 of them, so the maintenance rate stands in for the missing steps rather than a number the company has stated.
Value Scores are 58.7 for ShedRx and 45.1 for Direct Meds, against a tirzepatide category floor of $169. ShedRx leads by 13.6 points, driven mostly by price.
| Program | Price /70 | Evidence /15 | Dose /10 | Membership /5 | Total /100 |
|---|---|---|---|---|---|
| ShedRx | 40.9 | 12.8 | 0 | 5 | 58.7 |
| Direct Meds | 29.6 | 10.5 | 0 | 5 | 45.1 |
Semaglutide
Plan pages: ShedRx plans · Direct Meds plans
At 2.4 mg/week, ShedRx is $249 a month all-in and Direct Meds is $297 — $48 apart, or $576 across a year. Over twelve months the totals are $2,988 (billed monthly) and $3,564 (billed monthly).
ShedRx prices semaglutide by dose: $175 per month at 0.25 mg rising to $249 at 2.4 mg, a difference of $74 a month between the bottom and top of the ladder. The company publishes no price at 0.5, 1, 1.7 mg, so those doses are left blank rather than estimated.
Direct Meds prices semaglutide by dose: $249 per month at 0.25 mg rising to $297 at 2.4 mg, a difference of $48 a month between the bottom and top of the ladder. The company publishes no price at 0.5, 1, 1.7 mg, so those doses are left blank rather than estimated.
ShedRx is cheaper at every dose where both publish a price, so the lead does not change as you titrate.
Value Scores are 54.0 for ShedRx and 45.9 for Direct Meds, against a semaglutide category floor of $129. ShedRx leads by 8.1 points, driven mostly by price.
Where the two programs differ
All-in monthly
ShedRx is cheaper month to month — $289 against $399, a gap of $110 every month, or $1,320 across a year if both rates hold.
Cancellation terms
Cancellation differs: ShedRx states Cancel before renewal, while Direct Meds states Per provider terms. Read this next to the twelve-month figures — a prepaid discount and a restrictive refund policy are the same decision.
Commitment
ShedRx asks for Month-to-month; Direct Meds asks for Monthly (no commitment indicated). This is the dimension most likely to change which program is actually cheaper for you, because the lowest rates on both sides are usually attached to the longest terms.
Evidence status
The two prices are not equally well evidenced. ShedRx's figure is provider-stated and Direct Meds's is reported. ShedRx rests on the stronger of the two, and the Value Score below reflects that — evidence quality is worth fifteen points and is not a tiebreaker we apply after the fact.
Twelve-month cost
Over twelve months the totals are $3,468 for ShedRx and $4,788 for Direct Meds. ShedRx is lower by $1,320 — a figure worth checking against the cancellation terms below, because a prepaid year is only cheaper if you stay on it.
Dose policy
Both price by dose, so both advertised figures understate the cost of a titration year. Compare the ladders above rather than the headline rates.
Membership fee
Neither charges a separate membership fee.
Shipping
Shipping is handled the same way by both — included in the quoted price.
What each record says
ShedRx Official site
ShedRx advertises accessible entry pricing ($175 semaglutide, $199 tirzepatide) but tiers upward with dose — $249 and $289 respectively at the maintenance basis.
It does not publicly name its compounding pharmacy; the record shows Partner pharmacies, so who actually makes the medication cannot be independently verified; commitment terms are Month-to-month; cancellation is Cancel before renewal; availability is stated as Most US states.
Evidence: provider-stated — taken from the provider's own published pages; checkout capture pending, captured . Source — shedrx.com pricing capture 2026-08-05
Watch: Start-vs-maintenance spread is among the widest in the index; budget on the maintenance figure.
Direct Meds Official site
Direct Meds offers compounded GLP-1s in multiple formats — sublingual and injectable — with all-inclusive pricing verified on its own product pages. Semaglutide runs $249–$297/mo and tirzepatide $299–$399/mo depending on format; the lower figures are for sublingual delivery.
It does not publicly name its compounding pharmacy; the record shows Partner 503A pharmacy (not publicly named), so who actually makes the medication cannot be independently verified; commitment terms are Monthly (no commitment indicated); cancellation is Per provider terms; availability is stated as Confirm at intake.
Evidence: reported — sourced from dated third-party reporting; first-party capture pending, captured . Source — rangeyourself.com, Direct Meds product pages verified 2026-07-25
Watch: Pricing varies by format and page; product-page 'all-inclusive' rates differ from homepage promo cards. Rank is based on injectable rate as primary. Reported status — RangeYourself verified 2026-07-25 on Direct Meds' own product pages.
What neither record tells you
ShedRx does not publish
- no tirzepatide price at 5, 7.5, 12.5, 15 mg per week
- no published twelve-month tirzepatide rate
- no semaglutide price at 0.5, 1, 1.7 mg per week
- no published twelve-month semaglutide rate
- no named compounding pharmacy
- no state-by-state availability list — it says Most US states
Direct Meds does not publish
- no tirzepatide price at 5, 7.5, 12.5, 15 mg per week
- no published twelve-month tirzepatide rate
- no semaglutide price at 0.5, 1, 1.7 mg per week
- no published twelve-month semaglutide rate
- no named compounding pharmacy
- no state-by-state availability list — it says Confirm at intake
- no specific cancellation or refund terms
Ask ShedRx and Direct Meds for each of those in writing before enrolling. A gap is not evidence of a problem; it does mean nothing can be checked against it.
What would change this answer
Evidence may be upgraded. Direct Meds carries a price we have not captured at checkout. A capture would move the evidence term and could reorder these two without any price changing.
Which one suits which reader
On the lowest standing monthly rate for tirzepatide, ShedRx Official site wins this matchup. And if you would rather trust a better-evidenced number, shedrx's price rests on stronger provenance.
Both figures should be checked at the provider's own checkout before you pay. ShedRx's tirzepatide price is provider-stated as of 2026-08-05; Direct Meds's is reported as of 2026-07-25.
Questions
Is ShedRx or Direct Meds cheaper for tirzepatide?
ShedRx is cheaper on all-in monthly cost at 10 mg/week: $289 against $399, a difference of $110 a month. All-in means the medication plus every mandatory recurring fee.
What is the twelve-month cost of ShedRx versus Direct Meds?
ShedRx works out to $3,468 across twelve months and Direct Meds to $4,788, on the plan terms each publishes.
Does ShedRx or Direct Meds raise the price as the dose goes up?
ShedRx: yes, it prices by dose. Direct Meds: yes, it prices by dose. Where one program is flat and the other is tiered, the cheaper of the two can change as you titrate upward.
How many ways do ShedRx and Direct Meds differ?
5 of the eight dimensions this site records: all-in monthly, twelve-month cost, dose policy, membership, shipping, commitment, cancellation terms and evidence status.
Which of ShedRx and Direct Meds names its pharmacy?
Neither. ShedRx records Partner pharmacies and Direct Meds records Partner 503A pharmacy (not publicly named). Without a named pharmacy, neither program's licensing or inspection history can be checked before you order.
How well evidenced are the ShedRx and Direct Meds prices?
ShedRx's tirzepatide figure is provider-stated — taken from the provider's own published pages; checkout capture pending — captured 2026-08-05. Direct Meds's is reported, captured 2026-07-25. Evidence status is worth fifteen points in the Value Score, so it is priced in rather than mentioned as an aside.
Which is cheaper for semaglutide?
ShedRx, at $249 a month all-in against $297 at 2.4 mg/week. The two programs do not necessarily lead on both medications.
Official sources: ShedRx official site · Direct Meds official site. Compounded tirzepatide and semaglutide are not FDA-approved products.