Head-to-head
ShedRx vs Enhance MD
Compared on both medications across the eight dimensions this database records. They differ on 5 of those eight. Enhance MD is cheaper on all-in tirzepatide at 10 mg/week, though on a flat-versus-tiered matchup the cheaper program can change further up the dose ladder.
The short answer
ShedRx is $289 a month all-in for tirzepatide; Enhance MD is $280. Over twelve months that is $3,468 against $3,360. Value Scores are 58.7 and 57.8 out of 100.
Tirzepatide
Plan pages: ShedRx plans · Enhance MD plans
At 10 mg/week, ShedRx is $289 a month all-in and Enhance MD is $280 — $9 apart, or $108 across a year. Over twelve months the totals are $3,468 (billed monthly) and $3,360 (billed monthly).
ShedRx prices tirzepatide by dose: $199 per month at 2.5 mg rising to $289 at 10 mg, a difference of $90 a month between the bottom and top of the ladder. The company publishes no price at 5, 7.5, 12.5, 15 mg, so those doses are left blank rather than estimated.
Enhance MD prices tirzepatide by dose: $169 per month at 2.5 mg rising to $280 at 10 mg, a difference of $111 a month between the bottom and top of the ladder. The company publishes no price at 5, 7.5, 12.5, 15 mg, so those doses are left blank rather than estimated.
| Dose | ShedRx | Rank | Enhance MD | Rank | Cheaper |
|---|---|---|---|---|---|
| 2.5 mg | $199 | 7/31 | $169 | 2/31 | Enhance MD by $30 |
| 5 mg | — | — | — | — | neither publishes |
| 7.5 mg | — | — | — | — | neither publishes |
| 10 mg | $289 | 11/27 | $280 | 9/27 | Enhance MD by $9 |
| 12.5 mg | — | — | — | — | neither publishes |
| 15 mg | — | — | — | — | neither publishes |
Enhance MD is cheaper at every dose where both publish a price, so the lead does not change as you titrate.
Across the 27 programs this database can rank on tirzepatide, ShedRx sits 8 of 27 on all-in monthly cost and Enhance MD sits 7. They are adjacent in the field, with nothing priced between them. The field median is $339 and the floor is $169, so both sit below the median. ShedRx is $120 above the cheapest tirzepatide program on record. Enhance MD is $111 above the cheapest tirzepatide program on record.
LillyDirect (Zepbound), the lowest FDA-approved tirzepatide channel here, is $449 a month — ShedRx undercuts it by $160, Enhance MD by $169. Compounded products are not FDA approved; insurance can reverse that comparison.
| Plan term | ShedRx | Enhance MD | Cheaper |
|---|---|---|---|
| Month to month | $289 | $280 | Enhance MD by $9 |
| Settled dose | ShedRx | Enhance MD | Difference |
|---|---|---|---|
| 2.5 mg | $2,388 | $2,028 | $360 apart |
| 10 mg | $3,468 | $3,360 | $108 apart |
ShedRx publishes no rate for 3-month term, 6-month term, 12-month term; Enhance MD publishes none for 3-month term, 6-month term, 12-month term. An unpublished term is not necessarily unavailable — it is unpriced in public, which you can only resolve by asking.
A titration year is not twelve months at the maintenance price. Stepping up roughly four weeks per dose before settling at 10 mg/week, the first twelve months work out to $3,378 on ShedRx and $3,249 on Enhance MD — $129 apart, and a different gap from the $108 you would get by multiplying the monthly difference by twelve. The ramp is cheaper than the settled rate on whichever program prices by dose, which is why a first-year quote and a steady-state quote are not the same number.
That calculation is partial: ShedRx publishes no price at 2 of the 6 doses and Enhance MD publishes no price at 2 of them, so the maintenance rate stands in for the missing steps rather than a number the company has stated.
Value Scores are 58.7 for ShedRx and 57.8 for Enhance MD, against a tirzepatide category floor of $169. ShedRx leads by 0.9 points, driven mostly by price.
| Program | Price /70 | Evidence /15 | Dose /10 | Membership /5 | Total /100 |
|---|---|---|---|---|---|
| ShedRx | 40.9 | 12.8 | 0 | 5 | 58.7 |
| Enhance MD | 42.2 | 10.5 | 0 | 5 | 57.8 |
Semaglutide
Plan pages: ShedRx plans · Enhance MD plans
At 2.4 mg/week, ShedRx is $249 a month all-in and Enhance MD is $212 — $37 apart, or $444 across a year. Over twelve months the totals are $2,988 (billed monthly) and $2,544 (billed monthly).
ShedRx prices semaglutide by dose: $175 per month at 0.25 mg rising to $249 at 2.4 mg, a difference of $74 a month between the bottom and top of the ladder. The company publishes no price at 0.5, 1, 1.7 mg, so those doses are left blank rather than estimated.
Enhance MD charges a flat $212 per month for semaglutide at every dose from 0.25 to 2.4 mg per week, so titrating upward does not change what you pay.
The lead changes with the dose. Between 0.25 mg and 2.4 mg it passes to Enhance MD. Pick on the dose you expect to settle at, not the headline.
Value Scores are 54.0 for ShedRx and 58.1 for Enhance MD, against a semaglutide category floor of $129. Enhance MD leads by 4.1 points, driven mostly by price.
Where the two programs differ
All-in monthly
Enhance MD is cheaper month to month — $280 against $289, a gap of $9 every month, or $108 across a year if both rates hold.
Cancellation terms
Cancellation differs: ShedRx states Cancel before renewal, while Enhance MD states Per provider terms. Read this next to the twelve-month figures — a prepaid discount and a restrictive refund policy are the same decision.
Commitment
ShedRx asks for Month-to-month; Enhance MD asks for Monthly, with a first-month discount on GLP-1 Core ($112 first month). This is the dimension most likely to change which program is actually cheaper for you, because the lowest rates on both sides are usually attached to the longest terms.
Evidence status
The two prices are not equally well evidenced. ShedRx's figure is provider-stated and Enhance MD's is reported. ShedRx rests on the stronger of the two, and the Value Score below reflects that — evidence quality is worth fifteen points and is not a tiebreaker we apply after the fact.
Twelve-month cost
Over twelve months the totals are $3,468 for ShedRx and $3,360 for Enhance MD. Enhance MD is lower by $108 — a figure worth checking against the cancellation terms below, because a prepaid year is only cheaper if you stay on it.
Dose policy
Both price by dose, so both advertised figures understate the cost of a titration year. Compare the ladders above rather than the headline rates.
Membership fee
Neither charges a separate membership fee.
Shipping
Shipping is handled the same way by both — included in the quoted price.
What each record says
ShedRx Official site
ShedRx advertises accessible entry pricing ($175 semaglutide, $199 tirzepatide) but tiers upward with dose — $249 and $289 respectively at the maintenance basis.
It does not publicly name its compounding pharmacy; the record shows Partner pharmacies, so who actually makes the medication cannot be independently verified; commitment terms are Month-to-month; cancellation is Cancel before renewal; availability is stated as Most US states.
Evidence: provider-stated — taken from the provider's own published pages; checkout capture pending, captured . Source — shedrx.com pricing capture 2026-08-05
Watch: Start-vs-maintenance spread is among the widest in the index; budget on the maintenance figure.
Enhance MD Official site
Enhance MD bundles GLP-1 medication inside a broader metabolic program including NAD+ coaching, lab testing every six months, and ongoing provider care. The price reflects the full metabolic bundle, not the GLP-1 alone; this makes Enhance MD's figures the least comparable in the database.
It does not publicly name its compounding pharmacy; the record shows Partner 503A pharmacy (not named), so who actually makes the medication cannot be independently verified; commitment terms are Monthly, with a first-month discount on GLP-1 Core ($112 first month); cancellation is Per provider terms; availability is stated as Confirm at intake.
Evidence: reported — sourced from dated third-party reporting; first-party capture pending, captured . Source — rangeyourself.com, Enhance MD verified 2026-07-14; price reflects metabolic bundle, not GLP-1 alone
Watch: Figures reflect the bundled metabolic program price, not GLP-1 medication alone. Comparing Enhance MD's $212–$322 to medication-only programs overstates the GLP-1 cost while understating the breadth of service included. The $169 microdosing figure is the most medication-proximate but involves a different dosing protocol. Reported — RangeYourself 2026-07-14.
What neither record tells you
ShedRx does not publish
- no tirzepatide price at 5, 7.5, 12.5, 15 mg per week
- no published twelve-month tirzepatide rate
- no semaglutide price at 0.5, 1, 1.7 mg per week
- no published twelve-month semaglutide rate
- no named compounding pharmacy
- no state-by-state availability list — it says Most US states
Enhance MD does not publish
- no tirzepatide price at 5, 7.5, 12.5, 15 mg per week
- no published twelve-month tirzepatide rate
- no published twelve-month semaglutide rate
- no named compounding pharmacy
- no state-by-state availability list — it says Confirm at intake
- no specific cancellation or refund terms
Ask ShedRx and Enhance MD for each of those in writing before enrolling. A gap is not evidence of a problem; it does mean nothing can be checked against it.
What would change this answer
Evidence may be upgraded. Enhance MD carries a price we have not captured at checkout. A capture would move the evidence term and could reorder these two without any price changing.
Which one suits which reader
On the lowest standing monthly rate for tirzepatide, Enhance MD Official site wins this matchup. And if you would rather trust a better-evidenced number, shedrx's price rests on stronger provenance.
Both figures should be checked at the provider's own checkout before you pay. ShedRx's tirzepatide price is provider-stated as of 2026-08-05; Enhance MD's is reported as of 2026-07-14.
Questions
Is ShedRx or Enhance MD cheaper for tirzepatide?
Enhance MD is cheaper on all-in monthly cost at 10 mg/week: $280 against $289, a difference of $9 a month. All-in means the medication plus every mandatory recurring fee.
What is the twelve-month cost of ShedRx versus Enhance MD?
ShedRx works out to $3,468 across twelve months and Enhance MD to $3,360, on the plan terms each publishes.
Does ShedRx or Enhance MD raise the price as the dose goes up?
ShedRx: yes, it prices by dose. Enhance MD: yes, it prices by dose. Where one program is flat and the other is tiered, the cheaper of the two can change as you titrate upward.
How many ways do ShedRx and Enhance MD differ?
5 of the eight dimensions this site records: all-in monthly, twelve-month cost, dose policy, membership, shipping, commitment, cancellation terms and evidence status.
Which of ShedRx and Enhance MD names its pharmacy?
Neither. ShedRx records Partner pharmacies and Enhance MD records Partner 503A pharmacy (not named). Without a named pharmacy, neither program's licensing or inspection history can be checked before you order.
How well evidenced are the ShedRx and Enhance MD prices?
ShedRx's tirzepatide figure is provider-stated — taken from the provider's own published pages; checkout capture pending — captured 2026-08-05. Enhance MD's is reported, captured 2026-07-14. Evidence status is worth fifteen points in the Value Score, so it is priced in rather than mentioned as an aside.
Which is cheaper for semaglutide?
Enhance MD, at $212 a month all-in against $249 at 2.4 mg/week. The two programs do not necessarily lead on both medications.
Official sources: ShedRx official site · Enhance MD official site. Compounded tirzepatide and semaglutide are not FDA-approved products.