Head-to-head
TMates vs Direct Meds
Compared on both medications across the eight dimensions this database records. They differ on 3 of those eight. TMates is cheaper on all-in tirzepatide at 10 mg/week, though on a flat-versus-tiered matchup the cheaper program can change further up the dose ladder.
The short answer
TMates is $297 a month all-in for tirzepatide; Direct Meds is $399. Over twelve months that is $2,004 against $4,788. Value Scores are 55.3 and 45.1 out of 100.
Tirzepatide
Plan pages: TMates plans · Direct Meds plans
At 10 mg/week, TMates is $297 a month all-in and Direct Meds is $399 — $102 apart, or $1,224 across a year. Over twelve months the totals are $2,004 (prepaid term) and $4,788 (billed monthly).
TMates charges a flat $297 per month for tirzepatide at every dose from 2.5 to 15 mg per week, so titrating upward does not change what you pay. The company publishes no price at 5, 7.5, 12.5, 15 mg, so those doses are left blank rather than estimated.
Direct Meds prices tirzepatide by dose: $299 per month at 2.5 mg rising to $399 at 10 mg, a difference of $100 a month between the bottom and top of the ladder. The company publishes no price at 5, 7.5, 12.5, 15 mg, so those doses are left blank rather than estimated.
| Dose | TMates | Rank | Direct Meds | Rank | Cheaper |
|---|---|---|---|---|---|
| 2.5 mg | $297 | 16/31 | $299 | 17/31 | TMates by $2 |
| 5 mg | — | — | — | — | neither publishes |
| 7.5 mg | — | — | — | — | neither publishes |
| 10 mg | $297 | 12/27 | $399 | 20/27 | TMates by $102 |
| 12.5 mg | — | — | — | — | neither publishes |
| 15 mg | — | — | — | — | neither publishes |
TMates is cheaper at every dose where both publish a price, so the lead does not change as you titrate.
Across the 27 programs this database can rank on tirzepatide, TMates sits 10 of 27 on all-in monthly cost and Direct Meds sits 22. There are 11 other programs priced between them. The field median is $339 and the floor is $169, so TMates is below the median and the other is above it. TMates is $128 above the cheapest tirzepatide program on record. Direct Meds is $230 above the cheapest tirzepatide program on record.
LillyDirect (Zepbound), the lowest FDA-approved tirzepatide channel here, is $449 a month — TMates undercuts it by $152, Direct Meds by $50. Compounded products are not FDA approved; insurance can reverse that comparison.
| Plan term | TMates | Direct Meds | Cheaper |
|---|---|---|---|
| Month to month | $297 | $399 | TMates by $102 |
| 12-month term | $167 | — | only TMates publishes this term |
| Settled dose | TMates | Direct Meds | Difference |
|---|---|---|---|
| 2.5 mg | $3,564 | $3,588 | $24 apart |
| 10 mg | $3,564 | $4,788 | $1,224 apart |
TMates publishes no rate for 3-month term, 6-month term; Direct Meds publishes none for 3-month term, 6-month term, 12-month term. An unpublished term is not necessarily unavailable — it is unpriced in public, which you can only resolve by asking.
A titration year is not twelve months at the maintenance price. Stepping up roughly four weeks per dose before settling at 10 mg/week, the first twelve months work out to $3,564 on TMates and $4,688 on Direct Meds — $1,124 apart, and a different gap from the $1,224 you would get by multiplying the monthly difference by twelve. The ramp is cheaper than the settled rate on whichever program prices by dose, which is why a first-year quote and a steady-state quote are not the same number.
That calculation is partial: TMates publishes no price at 2 of the 6 doses and Direct Meds publishes no price at 2 of them, so the maintenance rate stands in for the missing steps rather than a number the company has stated.
Value Scores are 55.3 for TMates and 45.1 for Direct Meds, against a tirzepatide category floor of $169. TMates leads by 10.2 points, driven mostly by price.
| Program | Price /70 | Evidence /15 | Dose /10 | Membership /5 | Total /100 |
|---|---|---|---|---|---|
| TMates | 39.8 | 10.5 | 0 | 5 | 55.3 |
| Direct Meds | 29.6 | 10.5 | 0 | 5 | 45.1 |
Semaglutide
Plan pages: TMates plans · Direct Meds plans
At 2.4 mg/week, TMates is $249 a month all-in and Direct Meds is $297 — $48 apart, or $576 across a year. Over twelve months the totals are $1,896 (prepaid term) and $3,564 (billed monthly).
TMates charges a flat $249 per month for semaglutide at every dose from 0.25 to 2.4 mg per week, so titrating upward does not change what you pay. The company publishes no price at 0.5, 1, 1.7 mg, so those doses are left blank rather than estimated.
Direct Meds prices semaglutide by dose: $249 per month at 0.25 mg rising to $297 at 2.4 mg, a difference of $48 a month between the bottom and top of the ladder. The company publishes no price at 0.5, 1, 1.7 mg, so those doses are left blank rather than estimated.
TMates is cheaper at every dose where both publish a price, so the lead does not change as you titrate.
Value Scores are 51.8 for TMates and 45.9 for Direct Meds, against a semaglutide category floor of $129. TMates leads by 5.9 points, driven mostly by price.
Where the two programs differ
All-in monthly
TMates is cheaper month to month — $297 against $399, a gap of $102 every month, or $1,224 across a year if both rates hold.
Commitment
TMates asks for 12-month plan or month-to-month; substantial difference in rates; Direct Meds asks for Monthly (no commitment indicated). This is the dimension most likely to change which program is actually cheaper for you, because the lowest rates on both sides are usually attached to the longest terms.
Twelve-month cost
Over twelve months the totals are $2,004 for TMates and $4,788 for Direct Meds. TMates is lower by $2,784 — a figure worth checking against the cancellation terms below, because a prepaid year is only cheaper if you stay on it.
Cancellation terms
Both state the same cancellation terms: Per provider terms.
Dose policy
Both price by dose, so both advertised figures understate the cost of a titration year. Compare the ladders above rather than the headline rates.
Evidence status
Both figures carry the same evidence status, reported: sourced from dated third-party reporting; first-party capture pending. Neither is stronger than the other on provenance.
Membership fee
Neither charges a separate membership fee.
Shipping
Shipping is handled the same way by both — included in the quoted price.
What each record says
TMates Official site
TMates is a compounded GLP-1 telehealth service that includes medication and visits in one bundled monthly price. It offers both semaglutide and tirzepatide, with a 12-month plan that brings tirzepatide to $167/mo — the lowest committed-plan figure for tirz outside of bmiMD and NexLife.
It does not publicly name its compounding pharmacy; the record shows Partner 503A pharmacy (not publicly named), so who actually makes the medication cannot be independently verified; commitment terms are 12-month plan or month-to-month; substantial difference in rates; cancellation is Per provider terms; availability is stated as Confirm at intake.
Evidence: reported — sourced from dated third-party reporting; first-party capture pending, captured . Source — rangeyourself.com, capture 2026-07-14
Watch: The $158/mo (sema) and $167/mo (tirz) headline figures are 12-month plan rates; month-to-month is $249 (sema) and $297 (tirz) — some of the widest start-to-commitment spreads in the index. Reported status from RangeYourself 2026-07-14 verification.
Direct Meds Official site
Direct Meds offers compounded GLP-1s in multiple formats — sublingual and injectable — with all-inclusive pricing verified on its own product pages. Semaglutide runs $249–$297/mo and tirzepatide $299–$399/mo depending on format; the lower figures are for sublingual delivery.
It does not publicly name its compounding pharmacy; the record shows Partner 503A pharmacy (not publicly named), so who actually makes the medication cannot be independently verified; commitment terms are Monthly (no commitment indicated); cancellation is Per provider terms; availability is stated as Confirm at intake.
Evidence: reported — sourced from dated third-party reporting; first-party capture pending, captured . Source — rangeyourself.com, Direct Meds product pages verified 2026-07-25
Watch: Pricing varies by format and page; product-page 'all-inclusive' rates differ from homepage promo cards. Rank is based on injectable rate as primary. Reported status — RangeYourself verified 2026-07-25 on Direct Meds' own product pages.
What neither record tells you
TMates does not publish
- no tirzepatide price at 5, 7.5, 12.5, 15 mg per week
- no semaglutide price at 0.5, 1, 1.7 mg per week
- no named compounding pharmacy
- no state-by-state availability list — it says Confirm at intake
- no specific cancellation or refund terms
Direct Meds does not publish
- no tirzepatide price at 5, 7.5, 12.5, 15 mg per week
- no published twelve-month tirzepatide rate
- no semaglutide price at 0.5, 1, 1.7 mg per week
- no published twelve-month semaglutide rate
- no named compounding pharmacy
- no state-by-state availability list — it says Confirm at intake
- no specific cancellation or refund terms
Ask TMates and Direct Meds for each of those in writing before enrolling. A gap is not evidence of a problem; it does mean nothing can be checked against it.
What would change this answer
Evidence may be upgraded. TMates, Direct Meds carry a price we have not captured at checkout. A capture would move the evidence term and could reorder these two without any price changing.
Prepaid terms move the annual figures. TMates publishes a twelve-month rate of $167 a month against $297 month-to-month. Read those next to the cancellation terms, not the monthly rate.
Which one suits which reader
On the lowest standing monthly rate for tirzepatide, TMates Official site wins this matchup. On the structural dimensions the two are close enough that the choice comes down to availability in your state and which intake you prefer.
Both figures should be checked at the provider's own checkout before you pay. TMates's tirzepatide price is reported as of 2026-07-14; Direct Meds's is reported as of 2026-07-25.
Questions
Is TMates or Direct Meds cheaper for tirzepatide?
TMates is cheaper on all-in monthly cost at 10 mg/week: $297 against $399, a difference of $102 a month. All-in means the medication plus every mandatory recurring fee.
What is the twelve-month cost of TMates versus Direct Meds?
TMates works out to $2,004 across twelve months and Direct Meds to $4,788, on the plan terms each publishes.
Does TMates or Direct Meds raise the price as the dose goes up?
TMates: yes, it prices by dose. Direct Meds: yes, it prices by dose. Where one program is flat and the other is tiered, the cheaper of the two can change as you titrate upward.
How many ways do TMates and Direct Meds differ?
3 of the eight dimensions this site records: all-in monthly, twelve-month cost, dose policy, membership, shipping, commitment, cancellation terms and evidence status.
Which of TMates and Direct Meds names its pharmacy?
Neither. TMates records Partner 503A pharmacy (not publicly named) and Direct Meds records Partner 503A pharmacy (not publicly named). Without a named pharmacy, neither program's licensing or inspection history can be checked before you order.
How well evidenced are the TMates and Direct Meds prices?
TMates's tirzepatide figure is reported — sourced from dated third-party reporting; first-party capture pending — captured 2026-07-14. Direct Meds's is reported, captured 2026-07-25. Evidence status is worth fifteen points in the Value Score, so it is priced in rather than mentioned as an aside.
Which is cheaper for semaglutide?
TMates, at $249 a month all-in against $297 at 2.4 mg/week. The two programs do not necessarily lead on both medications.
Official sources: TMates official site · Direct Meds official site. Compounded tirzepatide and semaglutide are not FDA-approved products.