Head-to-head
TrimRx vs Direct Meds
Compared on both medications across the eight dimensions this database records. They differ on 6 of those eight. TrimRx is cheaper on all-in tirzepatide at 10 mg/week, though on a flat-versus-tiered matchup the cheaper program can change further up the dose ladder.
The short answer
TrimRx is $349 a month all-in for tirzepatide; Direct Meds is $399. Over twelve months that is $4,188 against $4,788. Value Scores are 61.6 and 45.1 out of 100.
Tirzepatide
Plan pages: TrimRx plans · Direct Meds plans
At 10 mg/week, TrimRx is $349 a month all-in and Direct Meds is $399 — $50 apart, or $600 across a year. Over twelve months the totals are $4,188 (billed monthly) and $4,788 (billed monthly).
TrimRx charges a flat $349 per month for tirzepatide at every dose from 2.5 to 15 mg per week, so titrating upward does not change what you pay.
Direct Meds prices tirzepatide by dose: $299 per month at 2.5 mg rising to $399 at 10 mg, a difference of $100 a month between the bottom and top of the ladder. The company publishes no price at 5, 7.5, 12.5, 15 mg, so those doses are left blank rather than estimated.
| Dose | TrimRx | Rank | Direct Meds | Rank | Cheaper |
|---|---|---|---|---|---|
| 2.5 mg | $349 | 25/31 | $299 | 17/31 | Direct Meds by $50 |
| 5 mg | $349 | 12/17 | — | — | only TrimRx publishes |
| 7.5 mg | $349 | 12/17 | — | — | only TrimRx publishes |
| 10 mg | $349 | 17/27 | $399 | 20/27 | TrimRx by $50 |
| 12.5 mg | $349 | 12/17 | — | — | only TrimRx publishes |
| 15 mg | $349 | 12/17 | — | — | only TrimRx publishes |
The lead changes with the dose. Between 2.5 mg and 10 mg it passes to TrimRx. Pick on the dose you expect to settle at, not the headline.
Across the 27 programs this database can rank on tirzepatide, TrimRx sits 15 of 27 on all-in monthly cost and Direct Meds sits 22. There are 6 other programs priced between them. The field median is $339 and the floor is $169, so both sit above the median. TrimRx is $180 above the cheapest tirzepatide program on record. Direct Meds is $230 above the cheapest tirzepatide program on record.
LillyDirect (Zepbound), the lowest FDA-approved tirzepatide channel here, is $449 a month — TrimRx undercuts it by $100, Direct Meds by $50. Compounded products are not FDA approved; insurance can reverse that comparison.
| Plan term | TrimRx | Direct Meds | Cheaper |
|---|---|---|---|
| Month to month | $349 | $399 | TrimRx by $50 |
| Settled dose | TrimRx | Direct Meds | Difference |
|---|---|---|---|
| 2.5 mg | $4,188 | $3,588 | $600 apart |
| 5 mg | $4,188 | — | one side unpriced |
| 7.5 mg | $4,188 | — | one side unpriced |
| 10 mg | $4,188 | $4,788 | $600 apart |
| 12.5 mg | $4,188 | — | one side unpriced |
| 15 mg | $4,188 | — | one side unpriced |
TrimRx publishes no rate for 3-month term, 6-month term, 12-month term; Direct Meds publishes none for 3-month term, 6-month term, 12-month term. An unpublished term is not necessarily unavailable — it is unpriced in public, which you can only resolve by asking.
A titration year is not twelve months at the maintenance price. Stepping up roughly four weeks per dose before settling at 10 mg/week, the first twelve months work out to $4,188 on TrimRx and $4,688 on Direct Meds — $500 apart, and a different gap from the $600 you would get by multiplying the monthly difference by twelve. The ramp is cheaper than the settled rate on whichever program prices by dose, which is why a first-year quote and a steady-state quote are not the same number.
That calculation is partial: Direct Meds publishes no price at 2 of them, so the maintenance rate stands in for the missing steps rather than a number the company has stated.
Value Scores are 61.6 for TrimRx and 45.1 for Direct Meds, against a tirzepatide category floor of $169. TrimRx leads by 16.5 points, and the margin comes from structure rather than price alone.
| Program | Price /70 | Evidence /15 | Dose /10 | Membership /5 | Total /100 |
|---|---|---|---|---|---|
| TrimRx | 33.9 | 12.8 | 10 | 5 | 61.6 |
| Direct Meds | 29.6 | 10.5 | 0 | 5 | 45.1 |
Semaglutide
Plan pages: TrimRx plans · Direct Meds plans
At 2.4 mg/week, TrimRx is $299 a month all-in and Direct Meds is $297 — $2 apart, or $24 across a year. Over twelve months the totals are $3,588 (billed monthly) and $3,564 (billed monthly).
TrimRx charges a flat $299 per month for semaglutide at every dose from 0.25 to 2.4 mg per week, so titrating upward does not change what you pay.
Direct Meds prices semaglutide by dose: $249 per month at 0.25 mg rising to $297 at 2.4 mg, a difference of $48 a month between the bottom and top of the ladder. The company publishes no price at 0.5, 1, 1.7 mg, so those doses are left blank rather than estimated.
Direct Meds is cheaper at every dose where both publish a price, so the lead does not change as you titrate.
Value Scores are 58.0 for TrimRx and 45.9 for Direct Meds, against a semaglutide category floor of $129. TrimRx leads by 12.1 points, and the margin comes from structure rather than price alone.
Where the two programs differ
All-in monthly
TrimRx is cheaper month to month — $349 against $399, a gap of $50 every month, or $600 across a year if both rates hold.
Cancellation terms
Cancellation differs: TrimRx states Cancel before renewal, while Direct Meds states Per provider terms. Read this next to the twelve-month figures — a prepaid discount and a restrictive refund policy are the same decision.
Commitment
TrimRx asks for Month-to-month; Direct Meds asks for Monthly (no commitment indicated). This is the dimension most likely to change which program is actually cheaper for you, because the lowest rates on both sides are usually attached to the longest terms.
Dose policy
TrimRx charges one price at every dose; Direct Meds prices by dose. That difference usually matters more than the headline gap, because the tiered program's advertised figure describes the dose you start on, not the dose you settle at.
Evidence status
The two prices are not equally well evidenced. TrimRx's figure is provider-stated and Direct Meds's is reported. TrimRx rests on the stronger of the two, and the Value Score below reflects that — evidence quality is worth fifteen points and is not a tiebreaker we apply after the fact.
Twelve-month cost
Over twelve months the totals are $4,188 for TrimRx and $4,788 for Direct Meds. TrimRx is lower by $600 — a figure worth checking against the cancellation terms below, because a prepaid year is only cheaper if you stay on it.
Membership fee
Neither charges a separate membership fee.
Shipping
Shipping is handled the same way by both — included in the quoted price.
What each record says
TrimRx Official site
TrimRx pairs a personalized-program pitch with mid-pack pricing: $299 semaglutide at maintenance and $349 tirzepatide.
It does not publicly name its compounding pharmacy; the record shows Partner pharmacies, so who actually makes the medication cannot be independently verified; commitment terms are Month-to-month; cancellation is Cancel before renewal; availability is stated as Most US states.
Evidence: provider-stated — taken from the provider's own published pages; checkout capture pending, captured . Source — trimrx.com pricing capture 2026-08-05
Watch: Start price ($179) is well below the maintenance figure; compare on maintenance.
Direct Meds Official site
Direct Meds offers compounded GLP-1s in multiple formats — sublingual and injectable — with all-inclusive pricing verified on its own product pages. Semaglutide runs $249–$297/mo and tirzepatide $299–$399/mo depending on format; the lower figures are for sublingual delivery.
It does not publicly name its compounding pharmacy; the record shows Partner 503A pharmacy (not publicly named), so who actually makes the medication cannot be independently verified; commitment terms are Monthly (no commitment indicated); cancellation is Per provider terms; availability is stated as Confirm at intake.
Evidence: reported — sourced from dated third-party reporting; first-party capture pending, captured . Source — rangeyourself.com, Direct Meds product pages verified 2026-07-25
Watch: Pricing varies by format and page; product-page 'all-inclusive' rates differ from homepage promo cards. Rank is based on injectable rate as primary. Reported status — RangeYourself verified 2026-07-25 on Direct Meds' own product pages.
What neither record tells you
TrimRx does not publish
- no published twelve-month tirzepatide rate
- no published twelve-month semaglutide rate
- no named compounding pharmacy
- no state-by-state availability list — it says Most US states
Direct Meds does not publish
- no tirzepatide price at 5, 7.5, 12.5, 15 mg per week
- no published twelve-month tirzepatide rate
- no semaglutide price at 0.5, 1, 1.7 mg per week
- no published twelve-month semaglutide rate
- no named compounding pharmacy
- no state-by-state availability list — it says Confirm at intake
- no specific cancellation or refund terms
Ask TrimRx and Direct Meds for each of those in writing before enrolling. A gap is not evidence of a problem; it does mean nothing can be checked against it.
What would change this answer
Evidence may be upgraded. Direct Meds carries a price we have not captured at checkout. A capture would move the evidence term and could reorder these two without any price changing.
Which one suits which reader
On the lowest standing monthly rate for tirzepatide, TrimRx Official site wins this matchup. If you expect to titrate to the top of the ladder, trimrx's flat pricing is worth more than the headline gap suggests; and if you would rather trust a better-evidenced number, trimrx's price rests on stronger provenance.
Both figures should be checked at the provider's own checkout before you pay. TrimRx's tirzepatide price is provider-stated as of 2026-08-05; Direct Meds's is reported as of 2026-07-25.
Questions
Is TrimRx or Direct Meds cheaper for tirzepatide?
TrimRx is cheaper on all-in monthly cost at 10 mg/week: $349 against $399, a difference of $50 a month. All-in means the medication plus every mandatory recurring fee.
What is the twelve-month cost of TrimRx versus Direct Meds?
TrimRx works out to $4,188 across twelve months and Direct Meds to $4,788, on the plan terms each publishes.
Does TrimRx or Direct Meds raise the price as the dose goes up?
TrimRx: no, it charges one flat rate at every dose. Direct Meds: yes, it prices by dose. Where one program is flat and the other is tiered, the cheaper of the two can change as you titrate upward.
How many ways do TrimRx and Direct Meds differ?
6 of the eight dimensions this site records: all-in monthly, twelve-month cost, dose policy, membership, shipping, commitment, cancellation terms and evidence status.
Which of TrimRx and Direct Meds names its pharmacy?
Neither. TrimRx records Partner pharmacies and Direct Meds records Partner 503A pharmacy (not publicly named). Without a named pharmacy, neither program's licensing or inspection history can be checked before you order.
How well evidenced are the TrimRx and Direct Meds prices?
TrimRx's tirzepatide figure is provider-stated — taken from the provider's own published pages; checkout capture pending — captured 2026-08-05. Direct Meds's is reported, captured 2026-07-25. Evidence status is worth fifteen points in the Value Score, so it is priced in rather than mentioned as an aside.
Which is cheaper for semaglutide?
Direct Meds, at $297 a month all-in against $299 at 2.4 mg/week. The two programs do not necessarily lead on both medications.
Official sources: TrimRx official site · Direct Meds official site. Compounded tirzepatide and semaglutide are not FDA-approved products.