Head-to-head
TrimRx vs LifeMD
Compared on both medications across the eight dimensions this database records. They differ on 4 of those eight. TrimRx is cheaper on all-in tirzepatide at 10 mg/week, though on a flat-versus-tiered matchup the cheaper program can change further up the dose ladder.
The short answer
TrimRx is $349 a month all-in for tirzepatide; LifeMD is $746. Over twelve months that is $4,188 against $8,952. Value Scores are 61.6 and 38.6 out of 100.
Tirzepatide
Plan pages: TrimRx plans · LifeMD plans
At 10 mg/week, TrimRx is $349 a month all-in and LifeMD is $746 — $397 apart, or $4,764 across a year. Over twelve months the totals are $4,188 (billed monthly) and $8,952 (billed monthly).
TrimRx charges a flat $349 per month for tirzepatide at every dose from 2.5 to 15 mg per week, so titrating upward does not change what you pay.
LifeMD charges a flat $597 per month for tirzepatide at every dose from 2.5 to 15 mg per week, so titrating upward does not change what you pay.
| Dose | TrimRx | Rank | LifeMD | Rank | Cheaper |
|---|---|---|---|---|---|
| 2.5 mg | $349 | 25/31 | $597 | 31/31 | TrimRx by $248 |
| 5 mg | $349 | 12/17 | $597 | 17/17 | TrimRx by $248 |
| 7.5 mg | $349 | 12/17 | $597 | 17/17 | TrimRx by $248 |
| 10 mg | $349 | 17/27 | $597 | 26/27 | TrimRx by $248 |
| 12.5 mg | $349 | 12/17 | $597 | 17/17 | TrimRx by $248 |
| 15 mg | $349 | 12/17 | $597 | 17/17 | TrimRx by $248 |
TrimRx is cheaper at every dose where both publish a price, so the lead does not change as you titrate.
Across the 27 programs this database can rank on tirzepatide, TrimRx sits 15 of 27 on all-in monthly cost and LifeMD sits 26. There are 10 other programs priced between them. The field median is $339 and the floor is $169, so both sit above the median. TrimRx is $180 above the cheapest tirzepatide program on record. LifeMD is $577 above the cheapest tirzepatide program on record.
LillyDirect (Zepbound), the lowest FDA-approved tirzepatide channel here, is $449 a month — TrimRx undercuts it by $100, LifeMD by $-297. Compounded products are not FDA approved; insurance can reverse that comparison.
| Plan term | TrimRx | LifeMD | Cheaper |
|---|---|---|---|
| Month to month | $349 | $597 | TrimRx by $248 |
| Settled dose | TrimRx | LifeMD | Difference |
|---|---|---|---|
| 2.5 mg | $4,188 | $8,952 | $4,764 apart |
| 5 mg | $4,188 | $8,952 | $4,764 apart |
| 7.5 mg | $4,188 | $8,952 | $4,764 apart |
| 10 mg | $4,188 | $8,952 | $4,764 apart |
| 12.5 mg | $4,188 | $8,952 | $4,764 apart |
| 15 mg | $4,188 | $8,952 | $4,764 apart |
TrimRx publishes no rate for 3-month term, 6-month term, 12-month term; LifeMD publishes none for 3-month term, 6-month term, 12-month term. An unpublished term is not necessarily unavailable — it is unpriced in public, which you can only resolve by asking.
A titration year is not twelve months at the maintenance price. Stepping up roughly four weeks per dose before settling at 10 mg/week, the first twelve months work out to $4,188 on TrimRx and $8,952 on LifeMD. Both programs charge one flat rate, so the ramp costs the same as any other stretch of the year.
Value Scores are 61.6 for TrimRx and 38.6 for LifeMD, against a tirzepatide category floor of $169. TrimRx leads by 23.0 points, driven mostly by price.
| Program | Price /70 | Evidence /15 | Dose /10 | Membership /5 | Total /100 |
|---|---|---|---|---|---|
| TrimRx | 33.9 | 12.8 | 10 | 5 | 61.6 |
| LifeMD | 15.9 | 12.8 | 10 | 0 | 38.6 |
Semaglutide
Plan pages: TrimRx plans · LifeMD plans
At 2.4 mg/week, TrimRx is $299 a month all-in and LifeMD is $497 — $198 apart, or $2,376 across a year. Over twelve months the totals are $3,588 (billed monthly) and $5,964 (billed monthly).
TrimRx charges a flat $299 per month for semaglutide at every dose from 0.25 to 2.4 mg per week, so titrating upward does not change what you pay.
LifeMD charges a flat $348 per month for semaglutide at every dose from 0.25 to 2.4 mg per week, so titrating upward does not change what you pay.
TrimRx is cheaper at every dose where both publish a price, so the lead does not change as you titrate.
Value Scores are 58.0 for TrimRx and 40.9 for LifeMD, against a semaglutide category floor of $129. TrimRx leads by 17.1 points, driven mostly by price.
Where the two programs differ
All-in monthly
TrimRx is cheaper month to month — $349 against $746, a gap of $397 every month, or $4,764 across a year if both rates hold.
Cancellation terms
Cancellation differs: TrimRx states Cancel before renewal, while LifeMD states Cancel anytime. Read this next to the twelve-month figures — a prepaid discount and a restrictive refund policy are the same decision.
Membership fee
LifeMD charges a membership of $149 a month on top of the medication. That is already folded into the all-in figures above — it is broken out here because a membership is a recurring charge that continues even in a month you skip a shipment.
Twelve-month cost
Over twelve months the totals are $4,188 for TrimRx and $8,952 for LifeMD. TrimRx is lower by $4,764 — a figure worth checking against the cancellation terms below, because a prepaid year is only cheaper if you stay on it.
Commitment
Commitment terms read the same on both: Month-to-month.
Dose policy
Both hold one price across the whole dose ladder, so neither punishes titration and the monthly figures above are what you actually pay at 15 mg as well as at 2.5 mg.
Evidence status
Both figures carry the same evidence status, provider-stated: taken from the provider's own published pages; checkout capture pending. Neither is stronger than the other on provenance.
Shipping
Shipping is handled the same way by both — included in the quoted price.
What each record says
TrimRx Official site
TrimRx pairs a personalized-program pitch with mid-pack pricing: $299 semaglutide at maintenance and $349 tirzepatide.
It does not publicly name its compounding pharmacy; the record shows Partner pharmacies, so who actually makes the medication cannot be independently verified; commitment terms are Month-to-month; cancellation is Cancel before renewal; availability is stated as Most US states.
Evidence: provider-stated — taken from the provider's own published pages; checkout capture pending, captured . Source — trimrx.com pricing capture 2026-08-05
Watch: Start price ($179) is well below the maintenance figure; compare on maintenance.
LifeMD Official site
LifeMD attaches a $149/month program fee to medication pricing; its compounded tirzepatide all-in figure ($597) is the highest in our index, though its insurance-navigation pathway for brand products is a genuine strength.
It does not publicly name its compounding pharmacy; the record shows Partner pharmacies, so who actually makes the medication cannot be independently verified; commitment terms are Month-to-month; cancellation is Cancel anytime; availability is stated as 50 states.
Evidence: provider-stated — taken from the provider's own published pages; checkout capture pending, captured . Source — lifemd.com pricing capture 2026-08-05
Watch: Highest all-in compounded tirzepatide in the index; the value case rests on clinical service and insurance help, not price.
What neither record tells you
TrimRx does not publish
- no published twelve-month tirzepatide rate
- no published twelve-month semaglutide rate
- no named compounding pharmacy
- no state-by-state availability list — it says Most US states
LifeMD does not publish
- no published twelve-month tirzepatide rate
- no published twelve-month semaglutide rate
- no named compounding pharmacy
Ask TrimRx and LifeMD for each of those in writing before enrolling. A gap is not evidence of a problem; it does mean nothing can be checked against it.
What would change this answer
Neither program publishes a promotional rate with an end date, a prepaid term, or a price we have flagged for re-verification, so the comparison above is as stable as this dataset gets.
Which one suits which reader
On the lowest standing monthly rate for tirzepatide, TrimRx Official site wins this matchup. If you want to be able to pause without still paying, trimrx carries no membership.
Both figures should be checked at the provider's own checkout before you pay. TrimRx's tirzepatide price is provider-stated as of 2026-08-05; LifeMD's is provider-stated as of 2026-08-05.
Questions
Is TrimRx or LifeMD cheaper for tirzepatide?
TrimRx is cheaper on all-in monthly cost at 10 mg/week: $349 against $746, a difference of $397 a month. All-in means the medication plus every mandatory recurring fee.
What is the twelve-month cost of TrimRx versus LifeMD?
TrimRx works out to $4,188 across twelve months and LifeMD to $8,952, on the plan terms each publishes.
Does TrimRx or LifeMD raise the price as the dose goes up?
TrimRx: no, it charges one flat rate at every dose. LifeMD: no, it charges one flat rate at every dose. Where one program is flat and the other is tiered, the cheaper of the two can change as you titrate upward.
How many ways do TrimRx and LifeMD differ?
4 of the eight dimensions this site records: all-in monthly, twelve-month cost, dose policy, membership, shipping, commitment, cancellation terms and evidence status.
Which of TrimRx and LifeMD names its pharmacy?
Neither. TrimRx records Partner pharmacies and LifeMD records Partner pharmacies. Without a named pharmacy, neither program's licensing or inspection history can be checked before you order.
How well evidenced are the TrimRx and LifeMD prices?
TrimRx's tirzepatide figure is provider-stated — taken from the provider's own published pages; checkout capture pending — captured 2026-08-05. LifeMD's is provider-stated, captured 2026-08-05. Evidence status is worth fifteen points in the Value Score, so it is priced in rather than mentioned as an aside.
Which is cheaper for semaglutide?
TrimRx, at $299 a month all-in against $497 at 2.4 mg/week. The two programs do not necessarily lead on both medications.
Official sources: TrimRx official site · LifeMD official site. Compounded tirzepatide and semaglutide are not FDA-approved products.