Head-to-head
Yucca Health vs Direct Meds
Compared on both medications across the eight dimensions this database records. They differ on 6 of those eight. Yucca Health is cheaper on all-in tirzepatide at 10 mg/week, though on a flat-versus-tiered matchup the cheaper program can change further up the dose ladder.
The short answer
Yucca Health is $258 a month all-in for tirzepatide; Direct Meds is $399. Over twelve months that is $3,096 against $4,788. Value Scores are 73.6 and 45.1 out of 100.
Tirzepatide
Plan pages: Yucca Health plans · Direct Meds plans
At 10 mg/week, Yucca Health is $258 a month all-in and Direct Meds is $399 — $141 apart, or $1,692 across a year. Over twelve months the totals are $3,096 (billed monthly) and $4,788 (billed monthly).
Yucca Health charges a flat $258 per month for tirzepatide at every dose from 2.5 to 15 mg per week, so titrating upward does not change what you pay.
Direct Meds prices tirzepatide by dose: $299 per month at 2.5 mg rising to $399 at 10 mg, a difference of $100 a month between the bottom and top of the ladder. The company publishes no price at 5, 7.5, 12.5, 15 mg, so those doses are left blank rather than estimated.
| Dose | Yucca Health | Rank | Direct Meds | Rank | Cheaper |
|---|---|---|---|---|---|
| 2.5 mg | $258 | 13/31 | $299 | 17/31 | Yucca Health by $41 |
| 5 mg | $258 | 6/17 | — | — | only Yucca Health publishes |
| 7.5 mg | $258 | 6/17 | — | — | only Yucca Health publishes |
| 10 mg | $258 | 6/27 | $399 | 20/27 | Yucca Health by $141 |
| 12.5 mg | $258 | 6/17 | — | — | only Yucca Health publishes |
| 15 mg | $258 | 6/17 | — | — | only Yucca Health publishes |
Yucca Health is cheaper at every dose where both publish a price, so the lead does not change as you titrate.
Across the 27 programs this database can rank on tirzepatide, Yucca Health sits 6 of 27 on all-in monthly cost and Direct Meds sits 22. There are 15 other programs priced between them. The field median is $339 and the floor is $169, so Yucca Health is below the median and the other is above it. Yucca Health is $89 above the cheapest tirzepatide program on record. Direct Meds is $230 above the cheapest tirzepatide program on record.
LillyDirect (Zepbound), the lowest FDA-approved tirzepatide channel here, is $449 a month — Yucca Health undercuts it by $191, Direct Meds by $50. Compounded products are not FDA approved; insurance can reverse that comparison.
| Plan term | Yucca Health | Direct Meds | Cheaper |
|---|---|---|---|
| Month to month | $258 | $399 | Yucca Health by $141 |
| Settled dose | Yucca Health | Direct Meds | Difference |
|---|---|---|---|
| 2.5 mg | $3,096 | $3,588 | $492 apart |
| 5 mg | $3,096 | — | one side unpriced |
| 7.5 mg | $3,096 | — | one side unpriced |
| 10 mg | $3,096 | $4,788 | $1,692 apart |
| 12.5 mg | $3,096 | — | one side unpriced |
| 15 mg | $3,096 | — | one side unpriced |
Yucca Health publishes no rate for 3-month term, 6-month term, 12-month term; Direct Meds publishes none for 3-month term, 6-month term, 12-month term. An unpublished term is not necessarily unavailable — it is unpriced in public, which you can only resolve by asking.
A titration year is not twelve months at the maintenance price. Stepping up roughly four weeks per dose before settling at 10 mg/week, the first twelve months work out to $3,096 on Yucca Health and $4,688 on Direct Meds — $1,592 apart, and a different gap from the $1,692 you would get by multiplying the monthly difference by twelve. The ramp is cheaper than the settled rate on whichever program prices by dose, which is why a first-year quote and a steady-state quote are not the same number.
That calculation is partial: Direct Meds publishes no price at 2 of them, so the maintenance rate stands in for the missing steps rather than a number the company has stated.
Value Scores are 73.6 for Yucca Health and 45.1 for Direct Meds, against a tirzepatide category floor of $169. Yucca Health leads by 28.5 points, driven mostly by price.
| Program | Price /70 | Evidence /15 | Dose /10 | Membership /5 | Total /100 |
|---|---|---|---|---|---|
| Yucca Health | 45.9 | 12.8 | 10 | 5 | 73.6 |
| Direct Meds | 29.6 | 10.5 | 0 | 5 | 45.1 |
Semaglutide
Plan pages: Yucca Health plans · Direct Meds plans
At 2.4 mg/week, Yucca Health is $146 a month all-in and Direct Meds is $297 — $151 apart, or $1,812 across a year. Over twelve months the totals are $1,752 (billed monthly) and $3,564 (billed monthly).
Yucca Health charges a flat $146 per month for semaglutide at every dose from 0.25 to 2.4 mg per week, so titrating upward does not change what you pay.
Direct Meds prices semaglutide by dose: $249 per month at 0.25 mg rising to $297 at 2.4 mg, a difference of $48 a month between the bottom and top of the ladder. The company publishes no price at 0.5, 1, 1.7 mg, so those doses are left blank rather than estimated.
Yucca Health is cheaper at every dose where both publish a price, so the lead does not change as you titrate.
Value Scores are 89.6 for Yucca Health and 45.9 for Direct Meds, against a semaglutide category floor of $129. Yucca Health leads by 43.7 points, driven mostly by price.
Where the two programs differ
All-in monthly
Yucca Health is cheaper month to month — $258 against $399, a gap of $141 every month, or $1,692 across a year if both rates hold.
Cancellation terms
Cancellation differs: Yucca Health states Cancel before renewal, while Direct Meds states Per provider terms. Read this next to the twelve-month figures — a prepaid discount and a restrictive refund policy are the same decision.
Commitment
Yucca Health asks for Month-to-month; Direct Meds asks for Monthly (no commitment indicated). This is the dimension most likely to change which program is actually cheaper for you, because the lowest rates on both sides are usually attached to the longest terms.
Dose policy
Yucca Health charges one price at every dose; Direct Meds prices by dose. That difference usually matters more than the headline gap, because the tiered program's advertised figure describes the dose you start on, not the dose you settle at.
Evidence status
The two prices are not equally well evidenced. Yucca Health's figure is provider-stated and Direct Meds's is reported. Yucca Health rests on the stronger of the two, and the Value Score below reflects that — evidence quality is worth fifteen points and is not a tiebreaker we apply after the fact.
Twelve-month cost
Over twelve months the totals are $3,096 for Yucca Health and $4,788 for Direct Meds. Yucca Health is lower by $1,692 — a figure worth checking against the cancellation terms below, because a prepaid year is only cheaper if you stay on it.
Membership fee
Neither charges a separate membership fee.
Shipping
Shipping is handled the same way by both — included in the quoted price.
What each record says
Yucca Health Official site
Yucca pairs no-membership pricing with dose-flat rates: $146/month semaglutide and $258/month tirzepatide, both all-in.
It does not publicly name its compounding pharmacy; the record shows Partner 503A pharmacies, so who actually makes the medication cannot be independently verified; commitment terms are Month-to-month; cancellation is Cancel before renewal; availability is stated as Most US states.
Evidence: provider-stated — taken from the provider's own published pages; checkout capture pending, captured . Source — yuccahealth.com pricing capture 2026-08-05
Watch: Provider-stated from published pages; checkout capture pending.
Direct Meds Official site
Direct Meds offers compounded GLP-1s in multiple formats — sublingual and injectable — with all-inclusive pricing verified on its own product pages. Semaglutide runs $249–$297/mo and tirzepatide $299–$399/mo depending on format; the lower figures are for sublingual delivery.
It does not publicly name its compounding pharmacy; the record shows Partner 503A pharmacy (not publicly named), so who actually makes the medication cannot be independently verified; commitment terms are Monthly (no commitment indicated); cancellation is Per provider terms; availability is stated as Confirm at intake.
Evidence: reported — sourced from dated third-party reporting; first-party capture pending, captured . Source — rangeyourself.com, Direct Meds product pages verified 2026-07-25
Watch: Pricing varies by format and page; product-page 'all-inclusive' rates differ from homepage promo cards. Rank is based on injectable rate as primary. Reported status — RangeYourself verified 2026-07-25 on Direct Meds' own product pages.
What neither record tells you
Yucca Health does not publish
- no published twelve-month tirzepatide rate
- no published twelve-month semaglutide rate
- no named compounding pharmacy
- no state-by-state availability list — it says Most US states
Direct Meds does not publish
- no tirzepatide price at 5, 7.5, 12.5, 15 mg per week
- no published twelve-month tirzepatide rate
- no semaglutide price at 0.5, 1, 1.7 mg per week
- no published twelve-month semaglutide rate
- no named compounding pharmacy
- no state-by-state availability list — it says Confirm at intake
- no specific cancellation or refund terms
Ask Yucca Health and Direct Meds for each of those in writing before enrolling. A gap is not evidence of a problem; it does mean nothing can be checked against it.
What would change this answer
Evidence may be upgraded. Direct Meds carries a price we have not captured at checkout. A capture would move the evidence term and could reorder these two without any price changing.
Which one suits which reader
On the lowest standing monthly rate for tirzepatide, Yucca Health Official site wins this matchup. If you expect to titrate to the top of the ladder, yucca health's flat pricing is worth more than the headline gap suggests; and if you would rather trust a better-evidenced number, yucca health's price rests on stronger provenance.
Both figures should be checked at the provider's own checkout before you pay. Yucca Health's tirzepatide price is provider-stated as of 2026-08-05; Direct Meds's is reported as of 2026-07-25.
Questions
Is Yucca Health or Direct Meds cheaper for tirzepatide?
Yucca Health is cheaper on all-in monthly cost at 10 mg/week: $258 against $399, a difference of $141 a month. All-in means the medication plus every mandatory recurring fee.
What is the twelve-month cost of Yucca Health versus Direct Meds?
Yucca Health works out to $3,096 across twelve months and Direct Meds to $4,788, on the plan terms each publishes.
Does Yucca Health or Direct Meds raise the price as the dose goes up?
Yucca Health: no, it charges one flat rate at every dose. Direct Meds: yes, it prices by dose. Where one program is flat and the other is tiered, the cheaper of the two can change as you titrate upward.
How many ways do Yucca Health and Direct Meds differ?
6 of the eight dimensions this site records: all-in monthly, twelve-month cost, dose policy, membership, shipping, commitment, cancellation terms and evidence status.
Which of Yucca Health and Direct Meds names its pharmacy?
Neither. Yucca Health records Partner 503A pharmacies and Direct Meds records Partner 503A pharmacy (not publicly named). Without a named pharmacy, neither program's licensing or inspection history can be checked before you order.
How well evidenced are the Yucca Health and Direct Meds prices?
Yucca Health's tirzepatide figure is provider-stated — taken from the provider's own published pages; checkout capture pending — captured 2026-08-05. Direct Meds's is reported, captured 2026-07-25. Evidence status is worth fifteen points in the Value Score, so it is priced in rather than mentioned as an aside.
Which is cheaper for semaglutide?
Yucca Health, at $146 a month all-in against $297 at 2.4 mg/week. The two programs do not necessarily lead on both medications.
Official sources: Yucca Health official site · Direct Meds official site. Compounded tirzepatide and semaglutide are not FDA-approved products.